Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr
文献类型：期刊论文
| 作者 | Wu, QL; Song, B |
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2015 |
| 卷号 | 26期号:4页码:— |
| 关键词 | CATION-PI INTERACTIONS ALZHEIMERS-DISEASE NEUROFIBRILLARY DEGENERATION BIOLOGICAL RECOGNITION AROMATIC RINGS ALUMINUM WATER PATHWAYS REMOVAL VIRUS |
| ISSN号 | 1001-8042 |
| 通讯作者 | Song, B (reprint author), Chinese Acad Sci, Shanghai Inst Appl Phys, Div Interfacial Water, Shanghai 201800, Peoples R China. |
| 英文摘要 | Aluminium is widely used as an antimicrobial coagulant, food additive, and cookware. However, many reports indicate that aluminium may be a critical factor in many amyloid diseases, such as Alzheimer's disease and Parkinson's disease. Unfortunately, the underlying mechanism is still poorly understood, which limits efforts to prevent and treat these diseases. In this paper, using an ab initio method, we studied the interaction of Al-backbone ring structure with the pi-electron-rich sidechains of His, Phe, Trp, and Tyr. We found that in the absence of water, the Al-backbone ring can stably bind with those sidechains. In the presence of water, the Al-backbone ring can bind to the His sidechain and cannot bind to the other sidechains. As revealed by further investigations, this could be attributed to the fact that there was a coordinate bond of the Al-backbone ring with the His sidechain, while there were the pi-pi stacking and cation-pi-like interactions with the other sidechains. These findings potentially provide a molecular understanding of Al-related toxicity, and may be helpful in designing drugs for those aforementioned aluminum-linked diseases and encourage treatment of Al-polluted water. |
| 语种 | 英语 |
| WOS记录号 | WOS:000361645000016 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/24968]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Wu, QL,Song, B. Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(4):—. |
| APA | Wu, QL,&Song, B.(2015).Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr.NUCLEAR SCIENCE AND TECHNIQUES,26(4),—. |
| MLA | Wu, QL,et al."Interaction of Al-induced peptide backbone ring structure with the sidechains of His, Phe, Trp and Tyr".NUCLEAR SCIENCE AND TECHNIQUES 26.4(2015):—. |
入库方式： OAI收割
来源：上海应用物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。