Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease
文献类型：期刊论文
| 作者 | Tian, T; Zhang, JC; Lei, HZ; Ying, Z; Shi, JY; Hu, J; Huang, Q; Fan, CH; Sun, YH |
| 刊名 | NUCLEAR SCIENCE AND TECHNIQUES
 |
| 出版日期 | 2015 |
| 卷号 | 26期号:3页码:— |
| 关键词 | OXIDATIVE STRESS NEURODEGENERATIVE DISEASES RAPAMYCIN PROTECTS MOUSE MODEL CELL-DEATH COPPER METALS ZINC IRON ACCUMULATION |
| ISSN号 | 1001-8042 |
| 通讯作者 | Sun, YH (reprint author), Chinese Acad Sci, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China. |
| 英文摘要 | The contents and distributions of metal elements in the brain are closely related to neurodegenerative diseases. In this study, we examined Fe, Cu and Zn contents in the brain section associated with Parkinson's disease (PD) using synchrotron radiation X-ray fluorescence (SRXRF). PD mouse model induced by 1-methyl-4-phenyl-1,2,3,6-terahydropyridine (MPTP) was used for the elemental analysis (e.g., Fe, Cu and Zn) in the substantia nigra pars compacta (SNpc) region of mice brain tissue samples. We found that mice in the MPTP group had higher contents of Fe, Cu and Zn in the SNpc than the control group. After treating the PD mice with rapamycin, the contents of Fe, Cu and Zn were reduced, the dopamine neurons and motor function were rescued correspondingly. The results prompted that the SRXRF provided an ideal method for tracing and analyzing the metal elements in the brain section to assess the pathological changes of PD model and the therapeutic effect of drugs. |
| 语种 | 英语 |
| WOS记录号 | WOS:000358109700019 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25063]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Tian, T,Zhang, JC,Lei, HZ,et al. Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease[J]. NUCLEAR SCIENCE AND TECHNIQUES,2015,26(3):—. |
| APA | Tian, T.,Zhang, JC.,Lei, HZ.,Ying, Z.,Shi, JY.,...&Sun, YH.(2015).Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease.NUCLEAR SCIENCE AND TECHNIQUES,26(3),—. |
| MLA | Tian, T,et al."Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson's disease".NUCLEAR SCIENCE AND TECHNIQUES 26.3(2015):—. |
入库方式： OAI收割
来源：上海应用物理研究所
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