Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation
文献类型：期刊论文
| 作者 | Zhang, MQ; Zhou, L; Deng, QF; Xie, YY; Xiao, TQ; Cao, YZ; Zhang, JW; Chen, XM; Yin, XZ; Xiao, B |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2015 |
| 卷号 | 5页码:— |
| 关键词 | PHASE-CONTRAST HUMAN-BRAIN TOMOGRAPHY NETWORKS MICROSTRUCTURE VESSELS POINT MICE |
| ISSN号 | 2045-2322 |
| 通讯作者 | Xiao, B (reprint author), Cent S Univ, Xiangya Hosp, Dept Neurol, Changsha 410008, Hunan, Peoples R China. |
| 英文摘要 | The angioarchitecture is a fundamental aspect of brain development and physiology. However, available imaging tools are unsuited for non-destructive cerebral mapping of the functionally important three-dimensional (3D) vascular microstructures. To address this issue, we developed an ultra-high resolution 3D digitalized angioarchitectural map for rat brain, based on synchrotron radiation phase contrast imaging (SR-PCI) with pixel size of 5.92 mu m. This approach provides a systematic and detailed view of the cerebrovascular anatomy at the micrometer level without any need for contrast agents. From qualitative and quantitative perspectives, the present 3D data provide a considerable insight into the spatial vascular network for whole rodent brain, particularly for functionally important regions of interest, such as the hippocampus, pre-frontal cerebral cortex and the corpus striatum. We extended these results to synchrotron-based virtual micro-endoscopy, thus revealing the trajectory of targeted vessels in 3D. The SR-PCI method for systematic visualization of cerebral microvasculature holds considerable promise for wider application in life sciences, including 3D micro-imaging in experimental models of neurodevelopmental and vascular disorders. |
| 语种 | 英语 |
| WOS记录号 | WOS:000362346900001 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25089]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Zhang, MQ,Zhou, L,Deng, QF,et al. Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation[J]. SCIENTIFIC REPORTS,2015,5:—. |
| APA | Zhang, MQ.,Zhou, L.,Deng, QF.,Xie, YY.,Xiao, TQ.,...&Xiao, B.(2015).Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation.SCIENTIFIC REPORTS,5,—. |
| MLA | Zhang, MQ,et al."Ultra-high-resolution 3D digitalized imaging of the cerebral angioarchitecture in rats using synchrotron radiation".SCIENTIFIC REPORTS 5(2015):—. |
入库方式： OAI收割
来源：上海应用物理研究所
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