Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays
文献类型：期刊论文
| 作者 | Lu, N; Gao, AR; Dai, PF; Mao, HJ; Zuo, XL; Fan, CH; Wang, YL; Li, T |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2015 |
| 卷号 | 87期号:22页码:11203—11208 |
| ISSN号 | 0003-2700 |
| 关键词 | PROSTATE-SPECIFIC ANTIGEN LABEL-FREE DETECTION SILICON-NANOWIRE ELECTRICAL DETECTION LUNG-CANCER SENSOR ARRAYS DNA BIOSENSOR AMPLIFICATION TRANSISTOR |
| 通讯作者 | Wang, YL (reprint author), Chinese Acad Sci, Shanghai Inst Microsyst & Informat Technol, Sci & Technol Microsyst Lab, Shanghai 200050, Peoples R China. |
| 英文摘要 | A direct, rapid, highly sensitive and specific biosensor for detection of cancer biomarkers is desirable in early diagnosis and prognosis of cancer. However, the existing methods of detecting cancer biomarkers suffer from poor sensitivity as well as the requirement of enzymatic labeling or nanoparticle conjugations. Here, we proposed a two-channel PDMS microfluidic integrated CMOS-compatible silicon nanowire (SiNW) field-effect transistor arrays with potentially single use for label-free and ultrasensitive electrical detection of cancer biomarkers. The integrated nanowire arrays showed not only ultrahigh sensitivity of cytokeratin 19 fragment (CYFRA21-1) and prostate specific antigen (PSA) with detection to at least 1 fg/mL in buffer solution but also highly selectivity of discrimination from other similar cancer biomarkers. In addition, this method was used to detect both CYFRA21-1 and PSA real samples as low as 10 fg/mL in undiluted human serums. With its excellent properties and miniaturization, the integrated SiNW-FET device opens up great opportunities for a point-of-care test (POCT) for quick screening and early diagnosis of cancer and other complex diseases. |
| 语种 | 英语 |
| WOS记录号 | WOS:000365151000007 |
| 公开日期 | 2016-03-08 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/25090]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 推荐引用方式 GB/T 7714 | Lu, N,Gao, AR,Dai, PF,et al. Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays[J]. ANALYTICAL CHEMISTRY,2015,87(22):11203—11208. |
| APA | Lu, N.,Gao, AR.,Dai, PF.,Mao, HJ.,Zuo, XL.,...&Li, T.(2015).Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays.ANALYTICAL CHEMISTRY,87(22),11203—11208. |
| MLA | Lu, N,et al."Ultrasensitive Detection of Dual Cancer Biomarkers with Integrated CMOS-Compatible Nanowire Arrays".ANALYTICAL CHEMISTRY 87.22(2015):11203—11208. |
入库方式： OAI收割
来源：上海应用物理研究所
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