Stabilizing G-quadruplex DNA by methylazacalix[n] pyridine through shape-complementary interaction
文献类型：期刊论文
| 作者 | Guan, Ai-Jiao1; Shen, Meng-Jie2; Zhang, En-Xuan3; Li, Qian1; Wang, Li-Xia1; Xu, Li-Jin2; Xiang, Jun-Feng1; Tang, Ya-Lin1 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016-01-15 |
| 卷号 | 26期号:2页码:609-612 |
| 关键词 | G-quadruplexes Stabilize Circular dichroism Methylazacalix[n] pyridine Molecular docking |
| 英文摘要 | It is found that G-quadruplexes have important functions in biological systems, such as gene expression. Molecules which can stabilize the G-quadruplex structure may have potential application in regulating the expression of gene. A series of methylazacalix[n]pyridine (n = 4, 6, 7, 8, 9) has been tested to stabilize the intermolecular human telomeric G-quadruplex (T12 and H12), intramolecular TBA, c-kit and bcl-2 G-quadruplex by CD denaturation experiments. The results showed that only methylazacalix[6] pyridine (MACP6) can stabilize the intermolecular G-quadruplex formed from the 12 bp human telomere. Further studies evidenced that the shape-complementary binding mode was what contributed to the interaction between MACP6 and T12 G-quadruplex. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29705]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,Inst Chem, Beijing 100190, Peoples R China 2.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China 3.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Ai-Jiao,Shen, Meng-Jie,Zhang, En-Xuan,et al. Stabilizing G-quadruplex DNA by methylazacalix[n] pyridine through shape-complementary interaction[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(2):609-612. |
| APA | Guan, Ai-Jiao.,Shen, Meng-Jie.,Zhang, En-Xuan.,Li, Qian.,Wang, Li-Xia.,...&Tang, Ya-Lin.(2016).Stabilizing G-quadruplex DNA by methylazacalix[n] pyridine through shape-complementary interaction.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(2),609-612. |
| MLA | Guan, Ai-Jiao,et al."Stabilizing G-quadruplex DNA by methylazacalix[n] pyridine through shape-complementary interaction".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.2(2016):609-612. |
入库方式： OAI收割
来源：化学研究所
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