Organic nanoparticles formed by aggregation-induced fluorescent molecules for detection of hydrogen sulfide in living cells
文献类型：期刊论文
| 作者 | Zhang, Yi1,2; Huang, Xianhong3,4,5; Liu, Wenwen1,2; Zhang, Guanxin3,4,5; Zhang, Deqing3,4,5; Jiang, Xingyu1,2 |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 59期号:1页码:106-113 |
| 关键词 | hydrogen sulfide aggregation-induced emission cell mitochondria |
| 英文摘要 | Hydrogen sulfide (H2S) has been found to be the third most important endogenous gaseous signaling molecule after nitric oxide (NO) and carbonic oxide (CO) and plays crucial roles in living organisms and biological systems. Here we use aggregation-induced emission (ALE) of a small organic molecule (TPE-indo) to detect H2S in both solution and living cells. TPE-indo can target mitochondria and aggregate to fluoresce, which can serve as a sensor for monitoring H2S in the mitochondria. We regulate the fluorescence of ATE molecules by tuning the viscosity of the solution to form TPE-indo nanoparticles, constructing a probe for H2S with good selectivity and high sensitivity. The nucleophilic addition of HS- to the TPE-indo is crucial for the rapid H2S detection. The imaging and analysis of H2S in mitochondria of living cells with the probe demonstrate potential biological applications. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29703]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, Beijing Engn Res Ctr BioNanotechnol, Beijing 100190, Peoples R China 2.Natl Ctr Nanosci & Technol, Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 4.Key Lab Organ Solids, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yi,Huang, Xianhong,Liu, Wenwen,et al. Organic nanoparticles formed by aggregation-induced fluorescent molecules for detection of hydrogen sulfide in living cells[J]. SCIENCE CHINA-CHEMISTRY,2016,59(1):106-113. |
| APA | Zhang, Yi,Huang, Xianhong,Liu, Wenwen,Zhang, Guanxin,Zhang, Deqing,&Jiang, Xingyu.(2016).Organic nanoparticles formed by aggregation-induced fluorescent molecules for detection of hydrogen sulfide in living cells.SCIENCE CHINA-CHEMISTRY,59(1),106-113. |
| MLA | Zhang, Yi,et al."Organic nanoparticles formed by aggregation-induced fluorescent molecules for detection of hydrogen sulfide in living cells".SCIENCE CHINA-CHEMISTRY 59.1(2016):106-113. |
入库方式： OAI收割
来源：化学研究所
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