Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery
文献类型：期刊论文
| 作者 | Li, Dawei1,2; Bu, Yazhong1; Zhang, Lining3; Wang, Xing1; Yang, Yanyu1; Zhuang, Yaping1; Yang, Fei1; Shen, Hong1; Wu, Decheng1 |
| 刊名 | BIOMACROMOLECULES
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:1页码:291-300 |
| 英文摘要 | Here we demonstrate a type of pH and reduction dual-sensitive biodegradable micelles, which were self-assembled by a cationic polymer in an aqueous solution. Due to tumor cells or tissues showing low pH and high reduction concentration, these micelles possessed specific tumor targetability and maximal drug-release controllability inside tumor cells upon changes in physical and chemical environments, but presented good stability at physiological conditions. CCK-8 assay showed that the DOX-loaded micelles had a similar cytotoxicity for MCF-7 tumor cells as free DOX, and blank micelles had a very low cytotoxicity to the cells. Fluorescent microscopy observation revealed that the drug-loaded Micelles could be quickly internalized by endosomes to inhibit cancer cell growth. These results indicated these biodegradable micelles, as a novel and effective pH- and redox-responsive nanocarrier, have a potential to improve drug delivery and enhance the antitumor efficacy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29777]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China 2.309th Hosp PLA, Dept Orthopaed, Beijing 100094, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Ctr Rehabil, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Dawei,Bu, Yazhong,Zhang, Lining,et al. Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery[J]. BIOMACROMOLECULES,2016,17(1):291-300. |
| APA | Li, Dawei.,Bu, Yazhong.,Zhang, Lining.,Wang, Xing.,Yang, Yanyu.,...&Wu, Decheng.(2016).Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery.BIOMACROMOLECULES,17(1),291-300. |
| MLA | Li, Dawei,et al."Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(beta-hydroxyl amine) for Drug Delivery".BIOMACROMOLECULES 17.1(2016):291-300. |
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来源：化学研究所
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