Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells
文献类型：期刊论文
| 作者 | Yin, Nuoya; Yao, Xinglei; Qin, Zhanfen; Wang, Yuan-Liang; Faiola, Francesco |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 36期号:1页码:181-187 |
| 关键词 | Bisphenol A (BPA) Stem cell toxicology Neurotoxicity Embryonic stem cells (ESCs) Developmental toxicity Neural ectoderm |
| 英文摘要 | The adverse effects of environmental pollution on our well-being have been intensively studied with many in vitro and in vivo systems. In our group, we focus on stem cell toxicology due to the multitude of embryonic stem cell (ESC) properties which can be exerted in toxicity assays. In fact, ESCs can differentiate in culture to mimic embryonic development in vivo, or specifically to virtually any kind of somatic cells. Here, we used the toxicant Bisphenol A (BPA), a chemical known as a hazard to infants and children, and showed that our stem cell toxicology system was able to efficiently recapitulate most of the toxic effectsofBPApreviouslydetectedby in vitro system or animal tests. More precisely, we demonstrated that BPA affected the proper specification of germ layers during our in vitro mimicking of the embryonic development, as well as the establishment of neural ectoderm and neural progenitor cells. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000362983500022 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32521]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yin, Nuoya,Yao, Xinglei,Qin, Zhanfen,et al. Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2015,36(1):181-187. |
| APA | Yin, Nuoya,Yao, Xinglei,Qin, Zhanfen,Wang, Yuan-Liang,&Faiola, Francesco.(2015).Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,36(1),181-187. |
| MLA | Yin, Nuoya,et al."Assessment of Bisphenol A (BPA) neurotoxicity in vitro with mouse embryonic stem cells".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 36.1(2015):181-187. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。