Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element
文献类型：期刊论文
| 作者 | Sun, Li; Wang, Lixin; Wang, Zhe; He, Wei; Zhang, Shuping; Guo, Wenli; Qian, Yi; Ji, Hong; Rong, Haiqin; Liu, Sijin |
| 刊名 | MOLECULAR MEDICINE REPORTS
 |
| 出版日期 | 2015-04 |
| 卷号 | 11期号:4页码:3129-3133 |
| 关键词 | cadmium ferroportin iron responsive element iron availability |
| 英文摘要 | Cadmium (Cd) is a heavy metal that has detrimental effects on various organs. The widespread contamination of Cd in the environment, crops and food sources poses a severe threat to human health. Acute toxicities of Cd have been extensively investigated; however, the health impact of chronic low-dose exposure to Cd, particularly exposure under non-toxic concentrations, has yet to be elucidated. Furthermore, the toxic threshold of Cd is currently unknown. Ferroportin is the only known iron exporter in vertebrate cells, and it has an essential role in controlling iron egress from cells. To the best of our knowledge, the present study is the first to verify the regulation of ferroportin by Cd. Treatment with low-dose Cd (i.e. at sublethal concentrations, without undermining cell viability) increased the protein expression of ferroportin in macrophages, and this was associated with depleted cellular iron levels. Mechanistic investigations revealed that Cd modulated the ferroportin concentration at the translational level, via the iron responsive element located at the 5-untranslated region of ferroportin. In conclusion, these data provide evidence for the molecular basis by which Cd alters cellular iron availability through elevating concentrations of ferroportin. |
| 研究领域[WOS] | Oncology ; Medicine, Research & Experimental |
| WOS记录号 | WOS:000351711100107 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32528]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Sun, Li,Wang, Lixin,Wang, Zhe,et al. Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element[J]. MOLECULAR MEDICINE REPORTS,2015,11(4):3129-3133. |
| APA | Sun, Li.,Wang, Lixin.,Wang, Zhe.,He, Wei.,Zhang, Shuping.,...&Liu, Sijin.(2015).Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element.MOLECULAR MEDICINE REPORTS,11(4),3129-3133. |
| MLA | Sun, Li,et al."Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element".MOLECULAR MEDICINE REPORTS 11.4(2015):3129-3133. |
入库方式： OAI收割
来源：生态环境研究中心
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