Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals
文献类型：期刊论文
| 作者 | Ma, Juan; Liu, Rui; Wang, Xiang; Liu, Qian; Chen, Yunan; Valle, Russell P.; Zuo, Yi Y.; Xia, Tian; Liu, Sijin |
| 刊名 | ACS NANO
 |
| 出版日期 | 2015-10 |
| 卷号 | 9期号:10页码:10498-10515 |
| 关键词 | graphene oxide macrophages plasma membrane pro-inflammatory responses nanotoxicology |
| 英文摘要 | Graphene oxide (GO) is increasingly used in biomedical applications because it possesses not only the unique properties of graphene including large surface area and flexibility but also hydrophilicity and dispersibility in aqueous solutions. However, there are conflicting results on its biocompatibility and biosafety partially due to large variations in physicochemical properties of GO, and the role of these properties including lateral size in the biological or toxicological effects of GO is still unclear. In this study, we focused on the role of lateral size by preparing a panel of GO samples with differential lateral sizes using the same starting material. We found that, in comparison to its smaller counterpart, larger GO showed a stronger adsorption onto the plasma membrane with less phagocytosis, which elicited more robust interaction with toll-like receptors and more potent activation of NF-kappa B pathways. By contrast, smaller GO sheets were more likely taken up by cells. As a result, larger GO promoted greater M1 polarization, associated with enhanced production of inflammatory cytokines and recruitment of immune cells. The in vitro results correlated well with local and systemic inflammatory responses after GO administration into the abdominal cavity, lung, or bloodstream through the tail vein. Together, our study delineated the size-dependent M1 induction of macrophages and pro-inflammatory responses of GO in vitro and in vivo. Our data also unearthed the detailed mechanism underlying these effects: a size-dependent interaction between GO and the plasma membrane. |
| 研究领域[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| WOS记录号 | WOS:000363915300106 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32546]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Ma, Juan,Liu, Rui,Wang, Xiang,et al. Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals[J]. ACS NANO,2015,9(10):10498-10515. |
| APA | Ma, Juan.,Liu, Rui.,Wang, Xiang.,Liu, Qian.,Chen, Yunan.,...&Liu, Sijin.(2015).Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals.ACS NANO,9(10),10498-10515. |
| MLA | Ma, Juan,et al."Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals".ACS NANO 9.10(2015):10498-10515. |
入库方式： OAI收割
来源：生态环境研究中心
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