Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review
文献类型：期刊论文
| 作者 | Guo, Wenli; Zhang, Jie; Li, Wenjun; Xu, Ming; Liu, Sijin |
| 刊名 | JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA
 |
| 出版日期 | 2015-08-01 |
| 卷号 | 34期号:1页码:155-164 |
| 关键词 | Persistent organic pollutants Heavy metals Organophosphate pesticides Iron homeostasis Iron diseases Hepcidin Ferroportin |
| 英文摘要 | Environmental pollution has become one of the greatest problems in the world, and the concerns about environmental pollutants released by human activities from agriculture and industrial production have been continuously increasing. Although intense efforts have been made to understand the health effects of environmental pollutants, most studies have only focused on direct toxic effects and failed to simultaneously evaluate the long-term adaptive, compensatory and secondary impacts on health. Burgeoning evidence suggests that environmental pollutants may directly or indirectly give rise to disordered element homeostasis, such as for iron. It is crucially important to maintain concerted cellular and systemic iron metabolism. Otherwise, disordered iron metabolism would lead to cytotoxicity and increased risk for various diseases, including cancers. Thus, study on the effects of environmental pollutants upon iron homeostasis is urgently needed. In this review, we recapitulate the available findings on the direct or indirect impacts of environmental pollutants, including persistent organic pollutants (POPs), heavy metals and pesticides, on iron homeostasis and associated adverse health problems. In view of the unanswered questions, more efforts are warranted to investigate the disruptive effects of environmental pollutants on iron homeostasis and consequent toxicities. (C) 2015 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000362980400017 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32557]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Guo, Wenli,Zhang, Jie,Li, Wenjun,et al. Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review[J]. JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,2015,34(1):155-164. |
| APA | Guo, Wenli,Zhang, Jie,Li, Wenjun,Xu, Ming,&Liu, Sijin.(2015).Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review.JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA,34(1),155-164. |
| MLA | Guo, Wenli,et al."Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review".JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 34.1(2015):155-164. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。