Establishment of a novel orthotopic model of breast cancer metastasis to the lung
文献类型：期刊论文
| 作者 | Guo, Wenli; Zhang, Shuping; Liu, Sijin |
| 刊名 | ONCOLOGY REPORTS
 |
| 出版日期 | 2015-06 |
| 卷号 | 33期号:6页码:2992-2998 |
| 关键词 | breast cancer metastasis orthotopic model lung epithelial-mesenchymal transition |
| 英文摘要 | Breast cancer is the second leading cause of cancer-related death among women, and distant metastasis is responsible for the death of similar to 90% of these patients. However, despite recent advances, the underlying mechanisms responsible for breast cancer metastasis remain elusive. A great impediment to this is the lack of appropriate orthotopic models of breast cancer metastasis to distant organs. In the present study, we established a novel orthotopic model of breast cancer metastasis to the lungs in mice, where metastatic sublines of 4T1 cells revealed enhanced metastatic propensity to the lungs. All mice (100%) developed lung metastasis upon orthotopic implantation of a metastatic sUbline of 4T1 cells, in contrast to 10% of mice with lung metastasis for a subline derived from primary tumors and 60% of mice with lung metastasis for parental 4T1 cells. At the molecular level, significant epithelial-mesenchymal transition was characterized in these metastatic sublines, which is likely at least partially, responsible for the enhanced metastasis. These established cell lines provide a novel platform to study the relevant molecular basis of metastasis and metastasis-specific therapeutics. |
| 研究领域[WOS] | Oncology |
| WOS记录号 | WOS:000355058700041 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32569]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Guo, Wenli,Zhang, Shuping,Liu, Sijin. Establishment of a novel orthotopic model of breast cancer metastasis to the lung[J]. ONCOLOGY REPORTS,2015,33(6):2992-2998. |
| APA | Guo, Wenli,Zhang, Shuping,&Liu, Sijin.(2015).Establishment of a novel orthotopic model of breast cancer metastasis to the lung.ONCOLOGY REPORTS,33(6),2992-2998. |
| MLA | Guo, Wenli,et al."Establishment of a novel orthotopic model of breast cancer metastasis to the lung".ONCOLOGY REPORTS 33.6(2015):2992-2998. |
入库方式： OAI收割
来源：生态环境研究中心
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