Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element
文献类型：期刊论文
| 作者 | Qian, Yi; Yin, Chunyang; Chen, Yue; Zhang, Shuping; Jiang, Li; Wang, Fudi; Zhao, Meirong; Liu, Sijin |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2015-05 |
| 卷号 | 27期号:5页码:934-942 |
| 关键词 | Estrogen Ferroportin Iron Ovariectomy Estrogen response element |
| 英文摘要 | Ferroportin (FPN) is the only known iron exporter in mammalian cells, and is universally expressed in most types of cells. FPN signaling plays a crucial role in maintaining iron homeostasis through governing the level of intracellular iron. Serum iron storage is conversely related with the estrogen level in the female bodies, and women in post-menopause are possibly subjected to iron retention. However, the potential effects of estrogen on iron metabolism are not clearly understood. Here, FPN mRNA transcription in all selected estrogen receptor positive (ER+) cells was significantly reduced upon 17 beta-estradiol (E2) treatment; and this inhibitory effect could be attenuated by ER antagonist tamoxifen. Likewise, in murine bone marrow-derived macrophages (BMDMs), FPN reduction with elevated intracellular iron (reflected by increased ferritin) was observed in response to E2; however, ferritin level barely responded to E2 in FPN-null BMDMs. The observation of inhibition of FPN mRNA expression was not replicated in ER cells upon E2. A functional estrogen response element (ERE) was identified within the promoter of FPN, and this ERE was responsible for the suppressive effect of E2 on FPN expression. Moreover, ovariectomized (OVX) and sham-operated (SHAM) mice were used to further confirm the in vitro finding. The expression of hepatic FPN was induced in OVX mice, compared to that in the SHAM mice. Taken together, our results demonstrated that estrogen is involved in regulating FPN expression through a functional ERE on its promoter, providing additional insights into a vital role of estrogen in iron metabolism. (C) 2015 Elsevier Inc. All rights reserved. |
| 研究领域[WOS] | Cell Biology |
| WOS记录号 | WOS:000352038900005 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32570]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Qian, Yi,Yin, Chunyang,Chen, Yue,et al. Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element[J]. CELLULAR SIGNALLING,2015,27(5):934-942. |
| APA | Qian, Yi.,Yin, Chunyang.,Chen, Yue.,Zhang, Shuping.,Jiang, Li.,...&Liu, Sijin.(2015).Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element.CELLULAR SIGNALLING,27(5),934-942. |
| MLA | Qian, Yi,et al."Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element".CELLULAR SIGNALLING 27.5(2015):934-942. |
入库方式： OAI收割
来源：生态环境研究中心
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