Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides
文献类型：期刊论文
| 作者 | Bi, Jingjing; Zhao, Chuanfang; Cui, Wei; Zhang, Chaoli; Shan, Qiuli; Du, Yuguo |
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2015-08-14 |
| 卷号 | 412页码:56-65 |
| 关键词 | Thiooligosaccharides Glucocluster Mutivalent effect Con A Hemagglutination |
| 英文摘要 | Thioglycoside-containing trimannose analogs were designed and prepared to mimic the natural N-glycan core trisaccharide alpha-D-Man-(1 -> 3)-[alpha-D-Man-(1 -> 6)]-D-Man. (1 -> 6)-S-Linked trimannoside 1 and its trivalent cluster 2 were synthesized in 11 and 15 steps, respectively, taking advantages of the armed mannopyranosyl trichloroacetimidate as glycosyl donor. Hemagglutination inhibition of the two new thiomannotriose analogs was preliminarily examined. Comparing to the parent trimannoside alpha-D-Man-(1 -> 3)-[alpha-D-Man-(1 -> 6)]-D-Man-OMe, the cluster mannotrioside 2 presented a comparable binding affinity to Con A, while the monomer 6-S-trimannoside 1 exhibited a slightly lower inhibition ability. (C) 2015 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic |
| WOS记录号 | WOS:000357542000009 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32675]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Bi, Jingjing,Zhao, Chuanfang,Cui, Wei,et al. Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides[J]. CARBOHYDRATE RESEARCH,2015,412:56-65. |
| APA | Bi, Jingjing,Zhao, Chuanfang,Cui, Wei,Zhang, Chaoli,Shan, Qiuli,&Du, Yuguo.(2015).Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides.CARBOHYDRATE RESEARCH,412,56-65. |
| MLA | Bi, Jingjing,et al."Synthesis and affinities of C3-symmetric thioglycoside-containing trimannosides".CARBOHYDRATE RESEARCH 412(2015):56-65. |
入库方式： OAI收割
来源：生态环境研究中心
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