The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro
文献类型：期刊论文
| 作者 | Li, Lingxiangyu; Luisa Fernandez-Cruz, Maria; Connolly, Mona; Conde, Estefania; Fernandez, Marta; Schuster, Michael; Maria Navas, Jose |
| 刊名 | SCIENCE OF THE TOTAL ENVIRONMENT
 |
| 出版日期 | 2015-02-01 |
| 卷号 | 505期号:1页码:253-260 |
| 关键词 | ZnONPs CuNPs HepG2 Potentiation effect Cytotoxicity assays |
| 英文摘要 | Here we examined whether the addition of a non-toxic concentration (6.25 mu g/mL) of zinc oxide nanoparticles (ZnONPs: 19,35 and 57 nm, respectively) modulates the cytotoxicity of copper nanoparticles (CuNPs, 63 nm in size) in the human hepatoma cell line HepG2. The cytotoxic effect of CuNPs on HepG2 cells was markedly enhanced by the ZnONPs, the largest ZnONPs causing the highest increase in toxicity. However, CuNPs cytotoxicity was not affected by co-incubation with medium containing only zinc ions, indicating the increase in toxicity might be attributed to the particle form of ZnONPs. Transmission electron microscopy (TEM) revealed the presence of CuNPs and ZnONPs inside the cells co-exposed to both types of NP and outflow of cytoplasm through the damaged cell membrane. Inductively coupled plasma mass spectrometry (ICP-MS) determined an increase in the concentration of zinc and a decrease in that of copper in co-exposed cells. On the basis of these results, we propose that accumulation of large numbers of ZnONPs in the cells alters cellular membranes and the cytotoxicity of CuNPs is increased. (C) 2014 Elsevier B.V. All rights reserved. |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000347654900024 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32685]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Lingxiangyu,Luisa Fernandez-Cruz, Maria,Connolly, Mona,et al. The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2015,505(1):253-260. |
| APA | Li, Lingxiangyu.,Luisa Fernandez-Cruz, Maria.,Connolly, Mona.,Conde, Estefania.,Fernandez, Marta.,...&Maria Navas, Jose.(2015).The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro.SCIENCE OF THE TOTAL ENVIRONMENT,505(1),253-260. |
| MLA | Li, Lingxiangyu,et al."The potentiation effect makes the difference: Non-toxic concentrations of ZnO nanoparticles enhance Cu nanoparticle toxicity in vitro".SCIENCE OF THE TOTAL ENVIRONMENT 505.1(2015):253-260. |
入库方式： OAI收割
来源：生态环境研究中心
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