Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats
文献类型：期刊论文
| 作者 | Yin, Nuoya; Yao, Xinglei; Zhou, Qunfang; Faiola, Francesco; Jiang, Guibin |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2015-03-06 |
| 卷号 | 458期号:2页码:405-410 |
| 关键词 | Silver nanoparticles Body weight Neurotoxicity Glial fibrillary acidic protein (GFAP) Vitamin E |
| 英文摘要 | Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials; however, it remains unclear whether AgNPs induce neurotoxicity. Here, we investigated the potential neurological effects of AgNPs and the neuroprotective effect of vitamin E (VE). We found that intranasal instillation of AgNPs in neonatal Sprague-Dawley rats caused significant body weight loss. Moreover, histological examinations revealed activation of neuroglial cells with concomitant destruction of the granular layer of the cerebellum. Furthermore, western blot analyses showed an increase in the levels of the glial fibrillary acidic protein (GFAP), a marker of astrocyte activation. These observations suggest that AgNPs have significant neurotoxic effects on the rat cerebellum. Strikingly, oral administration of VE counterbalanced the toxic effects triggered by AgNPs. Taken together, our findings suggest that nasal administration of AgNPs may produce neurotoxicity in rats, and that VE supplementation attenuates these effects. (C) 2015 The Authors. Published by Elsevier Inc. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| WOS记录号 | WOS:000351482200031 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32696]  |
| 专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Yin, Nuoya,Yao, Xinglei,Zhou, Qunfang,et al. Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,458(2):405-410. |
| APA | Yin, Nuoya,Yao, Xinglei,Zhou, Qunfang,Faiola, Francesco,&Jiang, Guibin.(2015).Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,458(2),405-410. |
| MLA | Yin, Nuoya,et al."Vitamin E attenuates silver nanoparticle-induced effects on body weight and neurotoxicity in rats".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 458.2(2015):405-410. |
入库方式： OAI收割
来源：生态环境研究中心
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