Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations
文献类型：期刊论文
| 作者 | Zhu, Lifei; Li, Wei; Zha, Jinmiao; Wang, Zijian |
| 刊名 | ENVIRONMENTAL TOXICOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 30期号:6页码:693-703 |
| 关键词 | dicamba vitellogenin (VTG) sex steroid hormone endocrine disruptor rare minnow (Gobiocypris rarus) |
| 英文摘要 | Dicamba is a benzoic acid herbicide that has been detected in surface and ground water. The herbicide has been shown to have cytogeneic and DNA damaging effects and to cause organ damage in mammals; however, little is known about the endocrine disrupting effects of dicamba in fish. In this study, histological changes, plasma vitellogenin (VTG) and sex hormone levels, and mRNA expression of sex steroid hormone-related genes were determined in adult rare minnow exposed to environmentally relevant concentrations of dicamba (0, 0.05, 0.5, 5, and 50 g/L) for 40 days. The results showed inhibition of spermatogenesis in male testes and ovarian degeneration in females. Plasma 17-estradiol (E2) levels were significantly increased in both genders, and plasma VTG levels were significantly increased in males (p<0.05). These results indicate that sex hormone homeostasis and normal reproduction of fish could be affected by dicamba. Moreover, the mRNA levels of vtg were significantly upregulated in the livers and gonads of both male and female rare minnows (p < 0.05). The downregulation of cytochrome P450c19a (cyp19a) and steroidogenic acute regulatory protein (star) mRNA levels, and the upregulation of cytochrome P450c17 (cyp17) mRNA levels were observed in the livers and ovaries (p<0.05). The results of the mRNA analysis suggest that changes in steroid hormone-related gene expression could serve as a regulatory mechanism to maintain sex hormone homeostasis. Overall, dicamba exposure could result in histological lesions, plasma VTG increases, changes in sex hormone levels, and alterations of hormone-related gene expression. Therefore, dicamba should be considered to be a potential endocrine disruptor. (c) 2014 Wiley Periodicals, Inc. Environ Toxicol 30: 693-703, 2015. |
| 研究领域[WOS] | Environmental Sciences ; Toxicology ; Water Resources |
| WOS记录号 | WOS:000354644200009 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32753]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhu, Lifei,Li, Wei,Zha, Jinmiao,et al. Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations[J]. ENVIRONMENTAL TOXICOLOGY,2015,30(6):693-703. |
| APA | Zhu, Lifei,Li, Wei,Zha, Jinmiao,&Wang, Zijian.(2015).Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations.ENVIRONMENTAL TOXICOLOGY,30(6),693-703. |
| MLA | Zhu, Lifei,et al."Dicamba affects sex steroid hormone level and mRNA expression of related genes in adult rare minnow (Gobiocypris rarus) at environmentally relevant concentrations".ENVIRONMENTAL TOXICOLOGY 30.6(2015):693-703. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。