Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea
文献类型：期刊论文
| 作者 | Chen, Huihui; Zha, Jinmiao; Yuan, Lilai; Wang, Zijian |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2015-01 |
| 卷号 | 119页码:856-862 |
| 关键词 | Fluoxetine C. fluminea Siphoning behavior Antioxidant enzymes Multixenobiotic resistance |
| 英文摘要 | Fluoxetine (FLX), a selective serotonin reuptake inhibitor, is widespread in aquatic environments. Despite its reported effects on behavior and reproduction in aquatic species, little is known about the effects of FLX on cellular detoxification and defense system in bivalves. Here, the adult Asian clam (Corbicula fluminea) was exposed to 0.5, 5, and 50 mu g L-1 FLX for 30 d. Siphoning behavior was inhibited by treatment with 50 mu g L-1 FLX. Additionally, superoxide dismutase (SOD) activity in the gills and digestive glands significantly decreased (p < 0.05) with 5 and 50 mu g L-1 FLX treatments, whereas catalase (CAT) activity and malondialdehyde (MDA) content markedly increased (p < 0.05). Moreover, transcription of thioredoxin reductase (TR), glutathione peroxidase (GPx) and Glutathione S-transferase pi class (GSTpi) was significantly upregulated (p < 0.05), whereas glutathione reductase (GR) was markedly downregulated (p < 0.05). These findings suggest that FLX affects behavior and induces oxidative stress in C. fluminea. The downregulation of ATP-binding cassette (ABC) transportor genes (ABCB1, ABCC1 and ABCG2) transporter genes indicated that FLX might suppress the multixenobiotic resistance (MXR) system in C. fluminea. Our results provide new insights into the adverse effects of FLX on the cellular detoxification and MXR system of C fluminea. (C) 2014 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Environmental Sciences |
| WOS记录号 | WOS:000347739600116 |
| 公开日期 | 2016-03-15 |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/32763]  |
| 专题 | 生态环境研究中心_环境水质学国家重点实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Huihui,Zha, Jinmiao,Yuan, Lilai,et al. Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea[J]. CHEMOSPHERE,2015,119:856-862. |
| APA | Chen, Huihui,Zha, Jinmiao,Yuan, Lilai,&Wang, Zijian.(2015).Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea.CHEMOSPHERE,119,856-862. |
| MLA | Chen, Huihui,et al."Effects of fluoxetine on behavior, antioxidant enzyme systems, and multixenobiotic resistance in the Asian clam Corbicula fluminea".CHEMOSPHERE 119(2015):856-862. |
入库方式： OAI收割
来源：生态环境研究中心
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