Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae
文献类型：期刊论文
| 作者 | Zhu, Biran1,2; Wang, Qiangwei1,2; Shi, Xiongjie3; Guo, Yongyong1; Xu, Tao4; Zhou, Bingsheng1 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 144页码:1646-1654 |
| 关键词 | Lead BDE-209 Co-exposure Developmental neurotoxicity ROS |
| ISSN号 | 0045-6535 |
| 英文摘要 | The effect of combined exposure to decabromodiphenyl ether (BDE-209) and lead (Pb) on neurodevelopment of zebrafish (Danio rerio) larvae was investigated. Zebrafish embryos were exposed to Pb (0, 5, 10, 20 mu g/L) and BDE-209 (0, 50, 100, 200 mu g/L), either alone or in combination (Mix1: 5 + 50 mu g/L, Mix2: 10 + 100 mu g/L, Mix3: 20 + 200 mu g/L) for up to 144 h post-fertilization. Growth of secondary motoneuron axons and expression of genes related to central nervous system development was significantly inhibited in Mix3 co-exposure group. A significant increase in reactive oxygen species (ROS), lipid peroxidation, DNA damage, and perturbation of the antioxidant system was detected in the Mix3 group compared to single-toxicant treatments or control. Depressed locomotor activity was recorded in the Mix2 and Mix3 groups. Addition of N-acetyl cysteine to Mix3 eliminated excessive ROS, and protected against lipid peroxidation, DNA damage, and locomotor dysfunction. Pb uptake was increased in the presence of BDE-209, but BDE-209 bioconcentration and the ability to metabolize BDE-209 were decreased in the presence of Pb. These results suggest that BDE-209 and Pb have a synergistic disruptive effect on neurodevelopment in zebrafish larvae by enhanced generation of ROS, which is a major factor that contributes to developmental neurotoxicity. (C) 2015 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences |
| 研究领域[WOS] | Environmental Sciences & Ecology |
| 关键词[WOS] | POLYBROMINATED DIPHENYL ETHERS ; WASTE RECYCLING AREA ; ORYZA-SATIVA L. ; OXIDATIVE STRESS ; HEAVY-METALS ; DEVELOPMENTAL NEUROTOXICITY ; ELECTRONIC-WASTE ; SOUTH CHINA ; NEURONAL DEVELOPMENT ; DEIODINASE FAMILY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000367774400209 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27589]  |
| 专题 | 水生生物研究所_鱼类生物学及渔业生物技术研究中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China 4.Huazhong Univ Sci & Technol, Puai Hosp, Wuhan 430033, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Biran,Wang, Qiangwei,Shi, Xiongjie,et al. Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae[J]. CHEMOSPHERE,2016,144:1646-1654. |
| APA | Zhu, Biran,Wang, Qiangwei,Shi, Xiongjie,Guo, Yongyong,Xu, Tao,&Zhou, Bingsheng.(2016).Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae.CHEMOSPHERE,144,1646-1654. |
| MLA | Zhu, Biran,et al."Effect of combined exposure to lead and decabromodiphenyl ether on neurodevelopment of zebrafish larvae".CHEMOSPHERE 144(2016):1646-1654. |
入库方式： OAI收割
来源：水生生物研究所
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