Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity
文献类型：期刊论文
| 作者 | Li, Q ; Tan, WQ; Zhang, CL; Gu, GD; Guo, ZY
|
| 刊名 | CARBOHYDRATE RESEARCH
 |
| 出版日期 | 2015-12-11 |
| 卷号 | 418页码:44-49 |
| 关键词 | Chitosan derivatives 1,2,3-Triazole Antifungal activity Aliphatic alcohol Chain length |
| ISSN号 | 0008-6215 |
| 产权排序 | [Li, Qing; Tan, Wenqiang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Tan, Wenqiang] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; [Zhang, Caili] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA |
| 通讯作者 | Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com |
| 英文摘要 | Chemical modification of chitosan is increasingly studied for its potential of providing new application for chitosan. Here, we modify chitosan at its primary hydroxyl via 'click chemistry', and a group of novel water soluble chitosan derivatives with substituted 1,2,3-triazolyl group were designed and synthesized. Aliphatic alcohols with different lengths were used as functional dendrons to improve the antifungal activity of chitosan derivatives. Meanwhile, their antifungal activity against two kinds of phytopathogens was estimated by hypha measurement in vitro. All the chitosan derivatives exhibited excellent activity against tested fungi. It is found that the antifungal activity of chitosan derivatives against the tested fungi increases with augment in the chain length of straight aliphatic alcohols. And the hydrophobic moiety (alkyl) at the periphery of the synthesized chitosan derivatives tends to affect their antifungal activity. (C) 2015 Elsevier Ltd. All rights reserved. |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | FREE CLICK CHEMISTRY ; QUATERNIZED CHITOSAN ; ANTIBACTERIAL ACTIVITY ; ANTITUMOR-ACTIVITY ; MAILLARD REACTION ; MOLECULAR-WEIGHT ; IN-VITRO ; INHIBITORS ; 1,2,4-TRIAZOLES ; ANTIOXIDANT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366219900006 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/9316]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 海岸带生物资源高效利用研究与发展中心 |
| 推荐引用方式 GB/T 7714 | Li, Q,Tan, WQ,Zhang, CL,et al. Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity[J]. CARBOHYDRATE RESEARCH,2015,418:44-49. |
| APA | Li, Q,Tan, WQ,Zhang, CL,Gu, GD,&Guo, ZY.(2015).Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity.CARBOHYDRATE RESEARCH,418,44-49. |
| MLA | Li, Q,et al."Novel triazolyl-functionalized chitosan derivatives with different chain lengths of aliphatic alcohol substituent: Design, synthesis, and antifungal activity".CARBOHYDRATE RESEARCH 418(2015):44-49. |
入库方式： OAI收割
来源：烟台海岸带研究所
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