alpha-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation
文献类型：期刊论文
| 作者 | Bai, Jia1,2; Zhang, Zeting1; Liu, Maili1; Li, Conggang1 |
| 刊名 | BMC BIOPHYSICS
 |
| 出版日期 | 2016-02-03 |
| 卷号 | 9 |
| 关键词 | alpha-synuclein (alpha S) Lanthanide metal ions Binding sites Fibrillation |
| 英文摘要 | Background: The pathological hallmark of Parkinson's disease is the deposition of cytoplasmic neuronal inclusions termed Lewy bodies. The major component of Lewy bodies is amyloid fibrils of alpha-synuclein. To investigate what causes alpha-synuclein aggregation is essential to understand its pathological roles in Parkinson's disease. Various metal ions, including iron and copper, have been implicated in the pathogenesis of Parkinson's disease. Divalent metal ions can regulate alpha-synuclein fibrillation rate, however, few studies have been performed to investigate how trivalent metal ions interact with alpha-synuclein and their effect on alpha-synuclein fibrillation. The study of the interaction between divalent and trivalent metal ions with alpha-synuclein is of vital importance to realize the mechanism of alpha-synuclein fibrillation. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biophysics |
| 研究领域[WOS] | Biophysics |
| 关键词[WOS] | RARE-EARTH-ELEMENTS ; PARKINSONS-DISEASE ; THIOFLAVIN-T ; STRUCTURAL-CHARACTERIZATION ; NEURODEGENERATIVE DISEASES ; AMYLOID FIBRILS ; TERMINAL DOMAIN ; NMR ; AGGREGATION ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369586100001 |
| 公开日期 | 2016-04-26 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9170]  |
| 专题 | 武汉物理与数学研究所_磁共振基础研究部 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Magnet Resonance Biol Syst, State Key Lab Magnet Resonance & Atom & Mol Phys, Natl Ctr Magnet Resonance Wuhan,Wuhan Inst Phys &, Wuhan 430071, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Jia,Zhang, Zeting,Liu, Maili,et al. alpha-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation[J]. BMC BIOPHYSICS,2016,9. |
| APA | Bai, Jia,Zhang, Zeting,Liu, Maili,&Li, Conggang.(2016).alpha-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation.BMC BIOPHYSICS,9. |
| MLA | Bai, Jia,et al."alpha-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation".BMC BIOPHYSICS 9(2016). |
入库方式： OAI收割
来源：武汉物理与数学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。