Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure
文献类型：期刊论文
| 作者 | Wan, Qianfen1; He, Qinghua2; Deng, Xianbai3; Hao, Fuhua1; Tang, Huiru4; Wang, Yulan1,5 |
| 刊名 | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| 出版日期 | 2016-01-27 |
| 卷号 | 64期号:3页码:714-723 |
| 关键词 | T-2 toxin metabonomics broiler chicken piglet |
| 英文摘要 | The aim of this study is to thoroughly investigate the toxicity mechanism of mycotoxin T-2 toxin and to further understand the endogenous metabolic alterations induced by T-2 toxin. To achieve this, a nuclear magnetic resonance (NMR)-based metabonomics approach was used to analyze the metabolic alterations induced by a single intravenous injection of T-2 toxin (0.5 mg/kg of body weight) in piglets and broiler chickens. A range of metabolites in the plasma, liver, kidney, and spleen of broiler chickens and plasma of piglets was changed following T-2 toxin injection. For example, a rapid increase of amino acids together with a significant reduction of glucose and lipid occurred in the plasma of broiler chickens and piglets following T-2 toxin treatment. A significant accumulation of amino acids and modulated nucleotides were detected in the liver, kidney, and spleen of T-2 toxin-treated broiler chickens. These data indicated that T-2 toxin caused endogenous metabolic changes in multiple organs and perturbed various metabolic pathways, including energy, amino acid, and nucleotide metabolism, as well as oxidative stress. We also observed elevated levels of tryptophan in the T-2 toxin-treated broiler chickens, which may explain the reported neurotoxic effects of T-2 toxin. These findings provide important information on the toxicity of T-2 toxin and demonstrate the power of the NMR-based metabonomics approach in exploring the toxicity mechanism of xenobiotics. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| 研究领域[WOS] | Agriculture ; Chemistry ; Food Science & Technology |
| 关键词[WOS] | EUKARYOTIC PROTEIN-SYNTHESIS ; DNA-DAMAGE ; ANALYTICAL REPRODUCIBILITY ; METABONOMIC ANALYSIS ; LIPID-PEROXIDATION ; OXIDATIVE STRESS ; LYMPHOID ORGANS ; GUINEA-PIGS ; TOXICITY ; RAT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369044200021 |
| 公开日期 | 2016-04-26 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9169]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Univ Chinese Acad Sci, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, CAS,Key Lab Magnet Resonance Biol Syst, Wuhan 430071, Hubei, Peoples R China 2.Shenzhen Univ, Dept Food Sci & Engn, Coll Chem & Environm Engn, Shenzhen 518060, Guangdong, Peoples R China 3.South China Agr Univ, Coll Vet Med, Guangzhou 510642, Guangdong, Peoples R China 4.Fudan Univ, State Key Lab Genet Engn, Collaborat Innovat Ctr Genet & Dev, Metabol & Syst Biol Lab,Sch Life Sci, Shanghai 200433, Peoples R China 5.Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wan, Qianfen,He, Qinghua,Deng, Xianbai,et al. Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016,64(3):714-723. |
| APA | Wan, Qianfen,He, Qinghua,Deng, Xianbai,Hao, Fuhua,Tang, Huiru,&Wang, Yulan.(2016).Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,64(3),714-723. |
| MLA | Wan, Qianfen,et al."Systemic Metabolic Responses of Broiler Chickens and Piglets to Acute T-2 Toxin Intravenous Exposure".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 64.3(2016):714-723. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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