Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear
文献类型：期刊论文
| 作者 | Yang, Hongbin1; Yang, Junhua1; Xi, Wang1; Hao, Sijia1; Luo, Benyan2; He, Xiaobin3,4; Zhu, Liya1; Lou, Huifang1; Yu, Yan-qin1; Xu, Fuqiang3,4,5 |
| 刊名 | NATURE NEUROSCIENCE
 |
| 出版日期 | 2016-02-01 |
| 卷号 | 19期号:2页码:283-+ |
| 英文摘要 | Innate fear has a critical role in survival of animals. Unlike conditioned fear, the neuronal circuitry underlying innate fear is largely unknown. We found that the laterodorsal tegmentum (LDT) and lateral habenula (LHb) are specifically activated by the mouse predator odorant trimethylthiazoline (TMT). Using optogenetics to selectively stimulate GABAergic neurons in the LDT immediately produced fear-like responses (freezing, accelerated heart rate and increased serum corticosterone), whereas prolonged stimulation caused anxiety-like behaviors. Notably, although selective stimulation of parvalbumin (PV)-positive interneurons similarly induced fear-like responses, stimulation of somatostatin-positive interneurons or inhibition of PV neurons in the LDT suppressed TMT-induced fear-like responses without affecting conditioned fear. Finally, activation of LHb glutamatergic inputs to LDT interneurons was sufficient to generate fear-like responses. Thus, the LHb-LDT pathway is important for regulating olfactory cue-induced innate fear. Our results provide a potential target for therapeutic intervention for anxiety disorder. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences |
| 研究领域[WOS] | Neurosciences & Neurology |
| 关键词[WOS] | PREDATOR ODOR ; VENTROMEDIAL HYPOTHALAMUS ; UNCONDITIONED FEAR ; LATERAL HABENULA ; FOX FECES ; NEURONS ; ANXIETY ; AMYGDALA ; RAT ; DEPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000369172600016 |
| 公开日期 | 2016-04-26 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9174]  |
| 专题 | 武汉物理与数学研究所_磁共振应用研究部 |
| 作者单位 | 1.Zhejiang Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China, Dept Neurobiol,Key Lab Med Neurobiol, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Hangzhou 310003, Zhejiang, Peoples R China 3.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, Key Lab Magnet Resonance Biol Syst, Wuhan, Peoples R China 4.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Peoples R China 5.Wuhan Natl Lab Optoelect, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Hongbin,Yang, Junhua,Xi, Wang,et al. Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear[J]. NATURE NEUROSCIENCE,2016,19(2):283-+. |
| APA | Yang, Hongbin.,Yang, Junhua.,Xi, Wang.,Hao, Sijia.,Luo, Benyan.,...&Wang, Hao.(2016).Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear.NATURE NEUROSCIENCE,19(2),283-+. |
| MLA | Yang, Hongbin,et al."Laterodorsal tegmentum interneuron subtypes oppositely regulate olfactory cue-induced innate fear".NATURE NEUROSCIENCE 19.2(2016):283-+. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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