UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway
文献类型：期刊论文
| 作者 | Hou,Zhiyao; Zhang,Yuanxin; Deng,Kerong; Chen,Yinyin; Li,Xuejiao; Deng,Xiaoran; Cheng,Ziyong; Lian,Hongzhou; Li,Chunxia; Lin,Jun |
| 刊名 | acs nano
 |
| 出版日期 | 2015 |
| 卷号 | 9期号:3页码:2584-2599 |
| 关键词 | BCL-2 FAMILY PROTEINS DRUG-DELIVERY CANCER-CELLS UPCONVERTING NANOPARTICLES NAYF4 NANOCRYSTALS POROUS NAYF4/YB3+ TITANIUM-DIOXIDE SINGLET OXYGEN SOLID TUMORS DEATH |
| 通讯作者 | lin,j |
| 英文摘要 | photodynamic therapy (pdt) is a promising anti-tumor treatment that is based on the photosensitizers that inhibit cancer cells by yielding reactive oxygen species (ros) after irradiation of light with specific wavelengths. as a potential photosensitizer; titanium dioxide (tio2) exhibits minimal dark cytotoxicity and excellent ultraviolet (uv) light triggered cytotoxitity, but is challenged by the limited tissue-penetration of uv light. herein, a novel near-infrared (nir) light activated photosensitizer for pdt based on tio2-coated upconversion nanoparticle (ucnp) core/shell nanocomposites (ucnps@tio2 ncs) is designed. nayf4:yb3+,tm3+@nagdf4:yb3+ core/shell ucnps can efficiently convert nir light to uv emission that matches well with the absorption of tio2 shells. the ucnp5@tio2 ncs endocytosed by cancer cells are able to generate intracellular ros under nir irradiation, decreasing the mitochondrial membrane votential to release cytochronne c into the cytosol and-then activating caspase 3 to induce cancer cell apoptosis. nir light triggered pdt of tumor-bearing mice with ucnps@tio2 as photosensitizers can suppress tumor growth efficiently due to the better tissue penetration than uv irradiation. on the basis of the evidence of in vitro and in vivo results, ucnps@tio2 ncs could serve as an effective photosensitizer for nir light mediated pdt in antitumor therapy. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351791800035 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64525]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Hou,Zhiyao,Zhang,Yuanxin,Deng,Kerong,et al. UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway[J]. acs nano,2015,9(3):2584-2599. |
| APA | Hou,Zhiyao.,Zhang,Yuanxin.,Deng,Kerong.,Chen,Yinyin.,Li,Xuejiao.,...&Lin,Jun.(2015).UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway.acs nano,9(3),2584-2599. |
| MLA | Hou,Zhiyao,et al."UV-Emitting Upconversion-Based TiO2 Photosensitizing Nanoplatform: Near-Infrared Light Mediated in Vivo Photodynamic Therapy via Mitochondria-Involved Apoptosis Pathway".acs nano 9.3(2015):2584-2599. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。