Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation
文献类型：期刊论文
| 作者 | Du,Zhi-Jun; Guan,Jing; Wu,Guo-Jie; Xu,Peng; Gao,Lian-Xun; Han,Fu-She |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2015 |
| 卷号 | 137期号:2页码:632-635 |
| 关键词 | MIYAURA COUPLING REACTIONS ASYMMETRIC-SYNTHESIS STEREOSELECTIVE-SYNTHESIS PHOSPHORUS LIGANDS CHIRAL LIGANDS ACTIVATION CATALYSIS OXIDES HYDROGENATION ACID |
| 通讯作者 | han,fs |
| 英文摘要 | we present the enantioselective synthesis of p-stereogenic phosphinamides through pd-catalyzed desymmetric ortho c-h arylation of diarylphosphinamides with boronic esters. the method represents the first example of the synthesis of p-stereogenic phosphorus compounds via the desymmetric c-h functionalization strategy. the reaction proceeded efficiently with a wide array of reaction partners to afford the p-stereogenic phosphinamides in up to 74% yield and 98% ee. the efficiency was further demonstrated by gram scale syntheses. moreover, the flexible conversion of the p-stereogenic phosphinamides into various types of p-stereogenic phosphorus derivatives was also elaborated. thus, the protocol provides a novel tool for the efficient and versatile synthesis of p-stereogenic compounds. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64528]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Du,Zhi-Jun,Guan,Jing,Wu,Guo-Jie,et al. Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation[J]. journal of the american chemical society,2015,137(2):632-635. |
| APA | Du,Zhi-Jun,Guan,Jing,Wu,Guo-Jie,Xu,Peng,Gao,Lian-Xun,&Han,Fu-She.(2015).Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation.journal of the american chemical society,137(2),632-635. |
| MLA | Du,Zhi-Jun,et al."Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C-H Arylation".journal of the american chemical society 137.2(2015):632-635. |
入库方式： OAI收割
来源：长春应用化学研究所
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