New Insights in Amyloid Beta Interactions with Human Telomerase
文献类型：期刊论文
| 作者 | Wang,Jiasi; Zhao,Chuanqi; Zhao,Andong; Li,Meng; Ren,Jinsong; Qu,Xiaogang |
| 刊名 | journal of the american chemical society
 |
| 出版日期 | 2015 |
| 卷号 | 137期号:3页码:1213-1219 |
| 关键词 | G-QUADRUPLEX DNA ALZHEIMERS-DISEASE A-BETA CATALYTIC SUBUNIT IN-VITRO CANCER THERAPEUTICS CATIONIC PORPHYRINS SECONDARY STRUCTURE PEPTIDE 25-35 BRAIN-INJURY |
| 通讯作者 | qu,xg |
| 英文摘要 | it is well-known that aging is the most risk factor for alzheimers disease (ad). recent studies have demonstrated that human telomerase is associated with pathological mechanisms of ad. in view of the central role of telomere and telomerase in the aging process, herein we found that the aggregated form a beta (a beta 1-40 and a beta 1-42), not a beta monomer, could inhibit telomerase activity both in vitro and in living cells. the beta-sheet structures were essential for a beta-induced telomerase inhibition. further studies indicated a beta oligomers inhibited telomerase activity through binding to dna center dot rna hybrid formed by telomeric dna and the rna template of telomerase, then blocking telomerase elongation of telomeric dna. we also identified that intracellular a beta localized at telomere, and induced cell senescence and telomere shortening. these results indicate that a beta oligomers can be potential natural inhibitors of telomerase and that inhibition of telomerase activity may be one of the factors for a beta-induced cytotoxicity. our work may offer a new clue to a better understanding of aging and ad. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64529]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wang,Jiasi,Zhao,Chuanqi,Zhao,Andong,et al. New Insights in Amyloid Beta Interactions with Human Telomerase[J]. journal of the american chemical society,2015,137(3):1213-1219. |
| APA | Wang,Jiasi,Zhao,Chuanqi,Zhao,Andong,Li,Meng,Ren,Jinsong,&Qu,Xiaogang.(2015).New Insights in Amyloid Beta Interactions with Human Telomerase.journal of the american chemical society,137(3),1213-1219. |
| MLA | Wang,Jiasi,et al."New Insights in Amyloid Beta Interactions with Human Telomerase".journal of the american chemical society 137.3(2015):1213-1219. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。