Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure
文献类型：期刊论文
| 作者 | Deng,Kerong; Hou,Zhiyao; Deng,Xiaoran; Yang,Piaoping; Li,Chunxia; Lin,Jun |
| 刊名 | advanced functional materials
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:47页码:7280-7290 |
| 关键词 | UP-CONVERSION NANOPARTICLES MESOPOROUS SILICA NANOPARTICLES IN-VIVO GRAPHENE OXIDE CANCER-CELLS THERANOSTIC AGENT DRUG-DELIVERY NANOCRYSTALS ABLATION TUMORS |
| 通讯作者 | deng,kr |
| 英文摘要 | a novel nanoplatform based on tungsten oxide (w18o49, wo) and indocyanine green (icg) for dual-modal photothermal therapy (ptt) and photodynamic therapy (pdt) has been successfully constructed. in this design, the hierarchical unique nanorod-bundled w18o49 nanostructures play roles in being not only as an efficient photothermal agent for ptt but also as a potential nanovehicle for icg molecules via electrostatic adsorption after modified with trimethylammonium groups on their surface. it is found that the ability of icg to produce cytotoxic reactive oxygen species for pdt is well maintained after being attached on the wo, thus the as-obtained wo@icg can achieve a synergistic effect of combined ptt and pdt under single 808 nm near-infrared (nir) laser excitation. notably, compared with ptt or pdt alone, the enhanced hela cells lethality of the 808 nm laser triggered dual-modal therapy is observed. the in vivo animal experiments have shown that wo@icg has effective solid tumor ablation effect with 808 nm nir light irradiation, revealing the potential of these nanocomposites as a nir-mediated dual-modal therapeutic platform for cancer treatment. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000366504100004 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64545]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Deng,Kerong,Hou,Zhiyao,Deng,Xiaoran,et al. Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure[J]. advanced functional materials,2015,25(47):7280-7290. |
| APA | Deng,Kerong,Hou,Zhiyao,Deng,Xiaoran,Yang,Piaoping,Li,Chunxia,&Lin,Jun.(2015).Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure.advanced functional materials,25(47),7280-7290. |
| MLA | Deng,Kerong,et al."Enhanced Antitumor Efficacy by 808 nm Laser-Induced Synergistic Photothermal and Photodynamic Therapy Based on a Indocyanine-Green-Attached W18O49 Nanostructure".advanced functional materials 25.47(2015):7280-7290. |
入库方式： OAI收割
来源：长春应用化学研究所
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