Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications
文献类型：期刊论文
| 作者 | Liu,Fuyao; He,Xiuxia; Chen,Hongda; Zhang,Junping; Zhang,Huimao; Wang,Zhenxin |
| 刊名 | nature communications
 |
| 出版日期 | 2015 |
| 卷号 | 6页码:8003 |
| 关键词 | MRI CONTRAST AGENT DRUG-DELIVERY MULTIFUNCTIONAL NANOPARTICLES BIOMEDICAL APPLICATIONS IN-VITRO PLATFORM THERAPY NANOMEDICINE SIZE ELIMINATION |
| 通讯作者 | zhang,hm |
| 英文摘要 | an ultrasmall hydrodynamic diameter is a critical factor for the renal clearance of nanoparticles from the body within a reasonable timescale. however, the integration of diagnostic and therapeutic components into a single ultrasmall nanoparticle remains challenging. in this study, ph-activated nanodots (termed fe-cpnds) composed of coordination polymers were synthesized via a simple and scalable method based on coordination reactions among fe3+, gallic acid and poly(vinylpyrrolidone) at ambient conditions. the fe-cpnds exhibited ultrasmall (5.3 nm) hydrodynamic diameters and electrically neutral surfaces. the fe-cpnds also exhibited ph-activatable magnetic resonance imaging contrast and outstanding photothermal performance. the features of fe-cpnds greatly increased the tumour-imaging sensitivity and facilitated renal clearance after injection in animal models in vivo. magnetic resonance imaging-guided photothermal therapy using fe-cpnds completely suppressed tumour growth. these findings demonstrate that fe-cpnds constitute a new class of renal clearable nanomedicine for photothermal therapy and molecular imaging. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360351200001 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64548]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu,Fuyao,He,Xiuxia,Chen,Hongda,et al. Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications[J]. nature communications,2015,6:8003. |
| APA | Liu,Fuyao,He,Xiuxia,Chen,Hongda,Zhang,Junping,Zhang,Huimao,&Wang,Zhenxin.(2015).Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications.nature communications,6,8003. |
| MLA | Liu,Fuyao,et al."Gram-scale synthesis of coordination polymer nanodots with renal clearance properties for cancer theranostic applications".nature communications 6(2015):8003. |
入库方式： OAI收割
来源：长春应用化学研究所
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