Deciphering a Nanocarbon-Based Artificial Peroxidase: Chemical Identification of the Catalytically Active and Substrate-Binding Sites on Graphene Quantum Dots
文献类型：期刊论文
| 作者 | Sun,Hanjun; Zhao,Andong; Gao,Nan; Li,Kai; Ren,Jinsong; Qu,Xiaogang |
| 刊名 | angewandte chemie-international edition
 |
| 出版日期 | 2015 |
| 卷号 | 54期号:24页码:7176-7180 |
| 关键词 | INITIO MOLECULAR-DYNAMICS TOTAL-ENERGY CALCULATIONS HIGH-RESOLUTION XPS WAVE BASIS-SET NANOPARTICLES NANOMATERIALS ENZYMES METALS |
| 通讯作者 | qu,xg |
| 英文摘要 | the design and construction of efficient artificial enzymes is highly desirable. recent studies have demonstrated that a series of carbon nanomaterials possess intrinsic peroxidase activity. among them, graphene quantum dots (gqds) have a high enzymatic activity. however, the catalytic mechanism remains unclear. therefore, in this report, we chose to decipher their peroxidase activity. by selectively deactivating the ketonic carbonyl, carboxylic, or hydroxy groups and investigating the catalytic activities of these gqd derivatives, we obtained evidence that the -c=o groups were the catalytically active sites, whereas the o=c-o- groups acted as substrate-binding sites, and -c-oh groups can inhibit the activity. these results were corroborated by theoretical studies. this work should not only enhance our understanding of nanocarbon-based artificial enzymes, but also facilitate the design and construction of other types of target-specific artificial enzymes. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000356385500042 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64557]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Sun,Hanjun,Zhao,Andong,Gao,Nan,et al. Deciphering a Nanocarbon-Based Artificial Peroxidase: Chemical Identification of the Catalytically Active and Substrate-Binding Sites on Graphene Quantum Dots[J]. angewandte chemie-international edition,2015,54(24):7176-7180. |
| APA | Sun,Hanjun,Zhao,Andong,Gao,Nan,Li,Kai,Ren,Jinsong,&Qu,Xiaogang.(2015).Deciphering a Nanocarbon-Based Artificial Peroxidase: Chemical Identification of the Catalytically Active and Substrate-Binding Sites on Graphene Quantum Dots.angewandte chemie-international edition,54(24),7176-7180. |
| MLA | Sun,Hanjun,et al."Deciphering a Nanocarbon-Based Artificial Peroxidase: Chemical Identification of the Catalytically Active and Substrate-Binding Sites on Graphene Quantum Dots".angewandte chemie-international edition 54.24(2015):7176-7180. |
入库方式： OAI收割
来源：长春应用化学研究所
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