Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models
文献类型：期刊论文
| 作者 | Li,Mingqiang; Tang,Zhaohui; Zhang,Dawei; Sun,Hai; Liu,Huaiyu; Zhang,Ying; Zhang,Yuanyuan; Chen,Xuesi |
| 刊名 | biomaterials
 |
| 出版日期 | 2015 |
| 卷号 | 51期号:7页码:161-172 |
| 关键词 | CANCER STEM-CELLS DRUG-DELIVERY POLYMERIC MICELLES BREAST-CANCER COLON-CANCER CO-DELIVERY CHEMICAL CARCINOGENESIS THERAPY MOUSE ACID |
| 通讯作者 | chen,xs |
| 英文摘要 | as a synergistic drug combination, doxorubicin-loaded cisplatin crosslinked polysaccharide-based nanoparticles (dex-sa-dox-cddp) have demonstrated enhanced antitumor efficacy and reduced systemic toxicity via optimized biodistribution, controlled drug release, prolonged blood circulation, and improved tolerability, compared to the non-crosslinked nanoparticles or free doxorubicin. herein, we apply the dex-sa-dox-cddp nanoparticles as an efficient antitumor agent to treat colorectal and breast tumors in three different in vivo models, i.e. subcutaneously implanted colorectal carcinoma, dimethylhydrazine-induced autochthonous colorectal carcinoma, and metastatic mammary carcinoma, which more closely simulate the natural milieu of the original tumor with intact pathological and immunological responses. based on the properties of this combination in higher tumor accumulation and penetrating efficiency, the dex-sa-dox-cddp nanoparticles significantly decreased the tumor sizes in ct26 cell line xenograft tumors compared to control. in addition, the affected animals' lifespan was significantly extended after the dex-sa-dox-cddp treatment, in the autochthonous colon cancer model. moreover, with the aid of irgd, dex-sa-dox-cddp could effectively block primary tumor growth and prevent the metastasis of 4t1 murine mammary carcinoma. in conclusion, dex-sa-dox-cddp nanoparticles remarkably inhibit growth of colorectal carcinoma and metastasis of mammary carcinoma in vivo, which provides potential application as a safe and efficient antitumor agent in treatment of these cancers. (c) 2015 elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000351796700016 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64586]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Li,Mingqiang,Tang,Zhaohui,Zhang,Dawei,et al. Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models[J]. biomaterials,2015,51(7):161-172. |
| APA | Li,Mingqiang.,Tang,Zhaohui.,Zhang,Dawei.,Sun,Hai.,Liu,Huaiyu.,...&Chen,Xuesi.(2015).Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models.biomaterials,51(7),161-172. |
| MLA | Li,Mingqiang,et al."Doxorubicin-loaded polysaccharide nanoparticles suppress the growth of murine colorectal carcinoma and inhibit the metastasis of murine mammary carcinoma in rodent models".biomaterials 51.7(2015):161-172. |
入库方式： OAI收割
来源：长春应用化学研究所
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