An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract
文献类型：期刊论文
| 作者 | Liu,Zhen; Liu,Jianhua; Wang,Rui; Du,Yingda; Ren,Jinsong; Qu,Xiaogang |
| 刊名 | biomaterials
 |
| 出版日期 | 2015 |
| 卷号 | 56期号:1页码:206-218 |
| 关键词 | RAY COMPUTED-TOMOGRAPHY UP-CONVERSION NANOPROBES SUPERPARAMAGNETIC IRON-OXIDE PEGYLATED W18O49 NANOWIRES CELLS IN-VIVO CONTRAST AGENTS PHOTODYNAMIC THERAPY GRAPHENE OXIDE GOLD NANORODS NANOPARTICLES |
| 通讯作者 | ren,js |
| 英文摘要 | since understanding the healthy status of gastrointestinal tract (gi tract) is of vital importance, clinical implementation for gi tract-related disease have attracted much more attention along with the rapid development of modern medicine. here, a multifunctional theranostic system combining x-rays/ct/photothermal/photoacoustic mapping of gi tract and imaging-guided photothermal anti-bacterial treatment is designed and constructed. pegylated w18o49 nanosheets (peg-w18o49) are created via a facile solvothermal method and an in situ probe-sonication approach. in terms of excellent colloidal stability, low cytotoxicity, and neglectable hemolysis of peg-w18o49, we demonstrate the first example of high-performance four-modal imaging of gi tract by using these nanosheets as contrast agents. more importantly, due to their intrinsic absorption of nir light, glutaraldehyde-modified peg-w18o49 are successfully applied as fault-free targeted photothermal agents for imaging-guided killing of bacteria on a mouse infection model. critical to pre-clinical and clinical prospects, long-term toxicity it further investigated after oral administration of these theranostic agents. these kinds of tungsten-based nanomaterials exhibit great potential as multi-modal contrast agents for directed visualization of gi tract and anti-bacterial agents for photnothermal sterilization. (c) 2015 elsevier ltd. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000355041600021 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64589]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Liu,Zhen,Liu,Jianhua,Wang,Rui,et al. An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract[J]. biomaterials,2015,56(1):206-218. |
| APA | Liu,Zhen,Liu,Jianhua,Wang,Rui,Du,Yingda,Ren,Jinsong,&Qu,Xiaogang.(2015).An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract.biomaterials,56(1),206-218. |
| MLA | Liu,Zhen,et al."An efficient nano-based theranostic system for multi-modal imaging-guided photothermal sterilization in gastrointestinal tract".biomaterials 56.1(2015):206-218. |
入库方式： OAI收割
来源：长春应用化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。