Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer
文献类型：期刊论文
| 作者 | Xu,Caina; Wang,Ping; Zhang,Jingpeng; Tian,Huayu; Park,Kinam; Chen,Xuesi |
| 刊名 | small
 |
| 出版日期 | 2015 |
| 卷号 | 11期号:34页码:4321-4333 |
| 关键词 | CO-DELIVERY INHALATION TREATMENT INHALED DOXORUBICIN PLGA MICROPARTICLES NONVIRAL VECTORS ANTICANCER DRUG GENE DELIVERY SYSTEM OLIGONUCLEOTIDES NANOCARRIER |
| 通讯作者 | tian,hy |
| 英文摘要 | a pulmonary codelivery system that can simultaneously deliver doxorubicin (dox) and bcl2 sirna to the lungs provides a promising local treatment strategy for lung cancers. in this study, dox is conjugated onto polyethylenimine (pei) by using cis-aconitic anhydride (ca, a ph-sensitive linker) to obtain pei-ca-dox conjugates. the pei-ca-dox/sirna complex nanoparticles are formed spontaneously via electrostatic interaction between cationic pei-ca-dox and anionic sirna. the drug release experiment shows that dox releases faster at acidic ph than at ph 7.4. moreover, pei-ca-dox/bcl2 sirna complex nanoparticles show higher cytotoxicity and apoptosis induction in b16f10 cells than those treated with either dox or bcl2 sirna alone. when the codelivery systems are directly sprayed into the lungs of b16f10 melanoma-bearing mice, the pei-ca-dox/bcl2 sirna complex nanoparticles exhibit enhanced antitumor efficacy compared with the single delivery of dox or bcl2 sirna. compared with systemic delivery, most drug and sirna show a long-term retention in the lungs via pulmonary delivery, and a considerable number of the drug and sirna accumulate in tumor tissues of lungs, but rarely in normal lung tissues. the pei-ca-dox/bcl2 sirna complex nanoparticles are promising for the treatment of metastatic lung cancer by pulmonary delivery with low side effects on the normal tissues. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360852900010 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64598]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu,Caina,Wang,Ping,Zhang,Jingpeng,et al. Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer[J]. small,2015,11(34):4321-4333. |
| APA | Xu,Caina,Wang,Ping,Zhang,Jingpeng,Tian,Huayu,Park,Kinam,&Chen,Xuesi.(2015).Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer.small,11(34),4321-4333. |
| MLA | Xu,Caina,et al."Pulmonary Codelivery of Doxorubicin and siRNA by pH-Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer".small 11.34(2015):4321-4333. |
入库方式： OAI收割
来源：长春应用化学研究所
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