Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy
文献类型：期刊论文
| 作者 | Yu,Haiyang; Tang,Zhaohui; Zhang,Dawei; Song,Wantong; Zhanga,Ying; Yang,Yan; Ahmad,Zaheer; Chen,Xuesi |
| 刊名 | journal of controlled release
 |
| 出版日期 | 2015 |
| 卷号 | 205期号:10页码:89-97 |
| 关键词 | INCORPORATED POLYMERIC MICELLES PLGA-MPEG NANOPARTICLES DRUG-DELIVERY ENHANCED PERMEABILITY ANTITUMOR EFFICACY TARGETED DELIVERY ANTICANCER DRUG SOLID TUMORS CO-DELIVERY CANCER |
| 通讯作者 | tang,zh |
| 英文摘要 | platinum-based polymeric nano-drugs, especially cisplatin-loaded polymeric nanoparticles (cddp-nps), have been extensively exploited for the treatment of solid tumors. however, it is still unclear what role the processing procedure and the properties of the polymeric carrier materials may play in influencing the plasma pharmacokinetics, biodistribution and in vivo efficacy of cddp-nps. in this study, a series of poly(l-glutamic acid)-g-methoxy poly(ethylene glycol) (plg-g-mpeg) copolymers were synthesized for the preparation of cddp-loaded plg-g-mpeg (cddp/plg-g-mpeg) nanoparticles. all of the parameters, including plg molecular weight, mpeg/plg weight ratio, mpeg chain length, ultrafiltration purification and cisplatin loading content, were found to have a significant influence on the plasma pharmacokinetics of the cddp/plg-g-mpeg nanoparticles. the blood circulation time of the nanoparticles was prolonged with increases in plg molecular weight, mpeg/plg weight ratio, mpeg chain length and cddp loading content. the use of ultrafiltration purification could prolong the blood circulation time of the nanoparticles as well. experiments to measure the pharmacokinetics and biodistribution demonstrated that the selected cddp/plg-g-mpeg nanoparticles, np10, had a long blood circulation time and could achieve selective and significant accumulation in lewis lung carcinoma (llc) tumors. the platinum plasma concentrations in the llc tumor-bearing mice receiving np10 remained up to 46-fold higher than that of mice receiving equivalent doses of free cddp. in addition, the plasma area under the concentration time curve (auc) of np10 was 31-fold higher than that of free cddp in 48 h. the platinum concentration ratio of np10 to free cddp in tumors reached as high as 9.4. the tumor auc ratio of np10 to cddp was 6. using a mouse c26 tumor model, here we demonstrate that np10 improves the safety and tolerance in vivo when compared to cddp and effectively inhibits the growth of c26 tumors. furthermore, increasing the dosage of np10 by 2 or 3-fold of free ccdp improved its anticancer efficacy to comparable or higher levels. these results indicate that cddp/plg-g-mpeg nanoparticles have greater potential for the treatment of solid tumors in clinical application. (c) 2014 elsevier b.v. all rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64609]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Yu,Haiyang,Tang,Zhaohui,Zhang,Dawei,et al. Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy[J]. journal of controlled release,2015,205(10):89-97. |
| APA | Yu,Haiyang.,Tang,Zhaohui.,Zhang,Dawei.,Song,Wantong.,Zhanga,Ying.,...&Chen,Xuesi.(2015).Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy.journal of controlled release,205(10),89-97. |
| MLA | Yu,Haiyang,et al."Pharmacokinetics, biodistribution and in vivo efficacy of cisplatin loaded poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) complex nanoparticles for tumor therapy".journal of controlled release 205.10(2015):89-97. |
入库方式： OAI收割
来源：长春应用化学研究所
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