Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment
文献类型：期刊论文
| 作者 | Chen,Yinyin; Liu,Bei; Deng,Xiaoran; Huang,Shanshan; Hou,Zhiyao; Li,Chunxia; Lin,Jun |
| 刊名 | nanoscale
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:18页码:8574-8583 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES CONTROLLED DRUG-DELIVERY IN-VIVO CANCER-THERAPY CELLS NANOSTRUCTURES TOXICITY |
| 通讯作者 | li,cx |
| 英文摘要 | core-shell structured nd3+-sensitized nayf4:yb/nd/er@nayf4:nd@msio(2) nanoparticles (nps) were designed and synthesized. the nayf4:yb/nd/er@nayf4:nd core imparts the nanomaterials with luminescence properties for upconversion optical imaging under 808 nm laser irradiation, whereas the mesoporous sio2 shell allows the nanomaterials to be loaded with anticancer drug doxorubicin (dox). in vivo toxicity assessment has confirmed that the nps have low systematic toxicity in healthy mice. in vivo antitumor activity shows that the nanocomposites exhibit greater antitumor efficacy than pure dox. as a result, the composite nanomaterials can serve as nanotheranostic materials for synchronous upconversion luminescence imaging under 808 nm laser irradiation, and as anticancer drug delivery vehicles, so as to integrate the diagnosis and treatment of cancers in vivo. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64666]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Chen,Yinyin,Liu,Bei,Deng,Xiaoran,et al. Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment[J]. nanoscale,2015,7(18):8574-8583. |
| APA | Chen,Yinyin.,Liu,Bei.,Deng,Xiaoran.,Huang,Shanshan.,Hou,Zhiyao.,...&Lin,Jun.(2015).Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment.nanoscale,7(18),8574-8583. |
| MLA | Chen,Yinyin,et al."Multifunctional Nd3+-sensitized upconversion nanomaterials for synchronous tumor diagnosis and treatment".nanoscale 7.18(2015):8574-8583. |
入库方式： OAI收割
来源：长春应用化学研究所
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