Gold nanocluster-based vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides
文献类型：期刊论文
| 作者 | Tao,Yu; Zhang,Yan; Ju,Enguo; Ten,Hui; Ren,Jinsong |
| 刊名 | nanoscale
 |
| 出版日期 | 2015 |
| 卷号 | 7期号:29页码:12419-12426 |
| 关键词 | MESOPOROUS SILICA NANOPARTICLES DENDRITIC CELL ACTIVATION ENHANCED IMMUNE-RESPONSE IN-VIVO CANCER-IMMUNOTHERAPY CPG OLIGONUCLEOTIDES TARGETED PARTICLES DNA NANOSTRUCTURES SYNTHETIC VACCINES DIRECTED SYNTHESIS |
| 通讯作者 | ren,h |
| 英文摘要 | we here report a facile one-pot synthesis of fluorescent gold nanoclusters (auncs) via the peptide bio-mineralization method, which can elicit specific immunological responses. the as-prepared peptide-protected auncs (peptide-auncs) display strong red fluorescence, and more importantly, as compared to the peptide alone, the immune stimulatory ability of the resulting peptide-auncs can not only be retained, but can also be efficaciously enhanced. moreover, through a dual-delivery of antigen peptides and cytosine-phosphate-guanine (cpg) oligodeoxynucleotides (odns), the as-prepared peptide-aunc-cpg conjugates can also act as smart self-vaccines to assist in the generation of high immunostimulatory activity, and be applied as a probe for intracellular imaging. both in vitro and in vivo studies provide strong evidence that the aunc-based vaccines may be utilized as safe and efficient immunostimulatory agents that are able to prevent and/or treat a variety of ailments. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358207700023 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64675]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Tao,Yu,Zhang,Yan,Ju,Enguo,et al. Gold nanocluster-based vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides[J]. nanoscale,2015,7(29):12419-12426. |
| APA | Tao,Yu,Zhang,Yan,Ju,Enguo,Ten,Hui,&Ren,Jinsong.(2015).Gold nanocluster-based vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides.nanoscale,7(29),12419-12426. |
| MLA | Tao,Yu,et al."Gold nanocluster-based vaccines for dual-delivery of antigens and immunostimulatory oligonucleotides".nanoscale 7.29(2015):12419-12426. |
入库方式： OAI收割
来源：长春应用化学研究所
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