Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease
文献类型：期刊论文
| 作者 | Wu,Li; Wang,Jiasi; Gao,Nan; Ren,Jinsong; Zhao,Andong; Qu,Xiaogang |
| 刊名 | nano research
 |
| 出版日期 | 2015 |
| 卷号 | 8期号:7页码:2400-2414 |
| 关键词 | A-BETA AGGREGATION NEURAL STEM-CELLS AMYLOID-BETA CONTROLLED-RELEASE POTENTIAL APPLICATION CONDUCTING-POLYMER HYDROGEN-PEROXIDE MESOPOROUS SILICA IN-VITRO CHELATOR |
| 通讯作者 | qu,xg |
| 英文摘要 | metal ions are involved in a beta aggregate deposition and neurotoxicity via various processes, including acceleration of a beta aggregation, disruption of normal metal homeostasis, and formation of reactive oxygen species (ros). although metal chelation is a promising therapeutic strategy for alzheimer's disease (ad), the widespread use of chelation therapy faces a significant problem; namely, it is difficult to differentiate toxic metals associated with a beta plaques from those required by normal metal homeostasis. furthermore, the multifactorial nature of ad and the current lack of an accepted unitary theory to account for ad neurodegeneration also restrict ad treatment through a single therapeutic strategy. this paper presents a novel bifunctional platform by integrating nonpharmacological and pharmacological cues into one system for ad treatment. this electrically responsive drug release platform, based on conducting polymer polypyrrole (ppy) incorporated with graphene-mesoporous silica nanohybrids (gsn) nanoreserviors, could realize on-demand controlled drug delivery with spatial and temporal control. electrochemical stimulation can treat peripheral nerve injury (pni) to stimulate neurite outgrowth. this novel system can also effectively inhibit a beta aggregate formation, decrease cellular ros, and protect cells from a beta-related toxicity. the purpose of this research is to promote the design of noninvasive remote-controlled multifunctional systems for ad treatment. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358052700028 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64687]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Wu,Li,Wang,Jiasi,Gao,Nan,et al. Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease[J]. nano research,2015,8(7):2400-2414. |
| APA | Wu,Li,Wang,Jiasi,Gao,Nan,Ren,Jinsong,Zhao,Andong,&Qu,Xiaogang.(2015).Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease.nano research,8(7),2400-2414. |
| MLA | Wu,Li,et al."Electrically pulsatile responsive drug delivery platform for treatment of Alzheimer's disease".nano research 8.7(2015):2400-2414. |
入库方式： OAI收割
来源：长春应用化学研究所
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