A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system
文献类型：期刊论文
| 作者 | Xu,Can; Shi,Peng,Li,Meng; Ren,Jinsong; Qu,Xiaogang |
| 刊名 | nano research
 |
| 出版日期 | 2015 |
| 卷号 | 8期号:7页码:2431-2444 |
| 关键词 | SUPPORTED PHOSPHOLIPID-BILAYERS RESPONSIVE CONTROLLED-RELEASE ALZHEIMERS-DISEASE TREATMENT SMALL-MOLECULE INHIBITORS NEAR-INFRARED ABSORBENCY ATOMIC-FORCE MICROSCOPY MESOPOROUS SILICA DRUG-DELIVERY BETA-PROTEIN IN-VIVO |
| 通讯作者 | ren,js |
| 英文摘要 | we report a new strategy for improving the efficiency of non-specific amyloidosis therapeutic drugs by coating amyloid-responsive lipid bilayers. the approach had drawn inspiration from amyloid oligomer-mediated cell membrane disruption in the pathogenesis of amyloidosis. a graphene-mesoporous silica hybrid (gms)-supported lipid bilayer (gms-lip) system was used as a drug carrier. drugs were well confined inside the nanocarrier until encountering amyloid oligomers, which could pierce the lipid bilayer coat and cause drug release. to ensure release efficiency, use of a near-infrared (nir) laser was also introduced to facilitate drug release, taking advantage of the photothermal effect of gms and thermal sensitivity of lipid bilayers. to facilitate tracking, fluorescent dyes were co-loaded with drugs within gms-lip and the nir laser was used once the oligomer-triggered release had been signaled. because of the spatially and temporally controllable property of light, the nir-assisted release could be easily and selectively activated locally, by tracking the fluorescence signal. our design is based on amyloidosis pathogenesis, the cytotoxic amyloid oligomer self-triggered release via cell membrane disruption, for the controlled release of drug molecules. the results may shed light on the development of pathogenesis-inspired drug delivery systems. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358052700030 |
| 源URL | [http://ir.ciac.jl.cn/handle/322003/64688]  |
| 专题 | 长春应用化学研究所_长春应用化学研究所知识产出_期刊论文 |
| 推荐引用方式 GB/T 7714 | Xu,Can,Shi,Peng,Li,Meng,Ren,Jinsong,et al. A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system[J]. nano research,2015,8(7):2431-2444. |
| APA | Xu,Can,Shi,Peng,Li,Meng,Ren,Jinsong,&Qu,Xiaogang.(2015).A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system.nano research,8(7),2431-2444. |
| MLA | Xu,Can,et al."A cytotoxic amyloid oligomer self-triggered and NIR-enhanced amyloidosis therapeutic system".nano research 8.7(2015):2431-2444. |
入库方式： OAI收割
来源：长春应用化学研究所
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