The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery
文献类型：期刊论文
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| 作者 | Yan L(晏亮) ; Chang YN(常亚南); Zhao LN(赵丽娜); Yan, L; Chang, YN; Zhao, LN; Gu, ZJ; Liu, XX; Tian, G; Zhou, LJ
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| 刊名 | CARBON
 ; CARBON
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| 出版日期 | 2013 ; 2013 |
| 卷号 | 57页码:120-129 |
| ISSN号 | 0008-6223 |
| DOI | 10.1016/j.carbon.2013.01.042 |
| 英文摘要 | In order to produce water-dispersible nanocrystals, including upconversion nanoparticles (UCNPs) which are the new generation fluorophores and magnetic nanoparticles (Fe3O4), a polyethylenimine-modified graphene oxide (PEI-GO) was used as a nanocarrier of nanocrystals, and PEI-GO-nanocrystal hybrids were prepared by transferring hydrophobic nanocrystals from an organic phase to water. Nanocrystals were anchored onto the hydrophobic plane of PEI-GO, which was confirmed by atomic force microscopy and electron microscopy. Molecular dynamics simulation further showed that hydrophobic interaction between PEI-GO and oleic acid molecules coated on the surface of the nanocrystals was the major driving force in the transfer process. The resulting hybrids had high stability in both water and physiological solutions, and combined the functionalities of the nanocrystals and PEI-GO, such as luminescence, superparamagnetism and drug delivery capability. Through pi-pi stacking interaction between PEI-GO-UCNP and an aromatic drug, PEI-GO-UCNP was able to load a water-insoluble anticancer drug, doxorubicin (DOX), with a superior loading capacity of 100 wt.%. In addition, PEI-GO-UCNP did not exhibit toxicity on the human endothelial cells and PEI-GO-UCNP-DOX showed a high potency of killing cancer cells in vitro. (C) 2013 Elsevier Ltd. All rights reserved.; In order to produce water-dispersible nanocrystals, including upconversion nanoparticles (UCNPs) which are the new generation fluorophores and magnetic nanoparticles (Fe3O4), a polyethylenimine-modified graphene oxide (PEI-GO) was used as a nanocarrier of nanocrystals, and PEI-GO-nanocrystal hybrids were prepared by transferring hydrophobic nanocrystals from an organic phase to water. Nanocrystals were anchored onto the hydrophobic plane of PEI-GO, which was confirmed by atomic force microscopy and electron microscopy. Molecular dynamics simulation further showed that hydrophobic interaction between PEI-GO and oleic acid molecules coated on the surface of the nanocrystals was the major driving force in the transfer process. The resulting hybrids had high stability in both water and physiological solutions, and combined the functionalities of the nanocrystals and PEI-GO, such as luminescence, superparamagnetism and drug delivery capability. Through pi-pi stacking interaction between PEI-GO-UCNP and an aromatic drug, PEI-GO-UCNP was able to load a water-insoluble anticancer drug, doxorubicin (DOX), with a superior loading capacity of 100 wt.%. In addition, PEI-GO-UCNP did not exhibit toxicity on the human endothelial cells and PEI-GO-UCNP-DOX showed a high potency of killing cancer cells in vitro. (C) 2013 Elsevier Ltd. All rights reserved. |
| 学科主题 | Chemistry; Materials Science ; Chemistry; Materials Science |
| 收录类别 | SCI |
| 电子版国际标准刊号 | 1873-3891 |
| 语种 | 英语 |
| WOS记录号 | WOS:000319030000013 ; WOS:000319030000013 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223855]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yan L,Chang YN,Zhao LN,et al. The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery, The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery[J]. CARBON, CARBON,2013, 2013,57, 57:120-129, 120-129. |
| APA | 晏亮.,常亚南.,赵丽娜.,Yan, L.,Chang, YN.,...&赵宇亮.(2013).The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery.CARBON,57,120-129. |
| MLA | 晏亮,et al."The use of polyethylenimine-modified graphene oxide as a nanocarrier for transferring hydrophobic nanocrystals into water to produce water-dispersible hybrids for use in drug delivery".CARBON 57(2013):120-129. |
入库方式： OAI收割
来源：高能物理研究所
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