The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces
文献类型：期刊论文
| 作者 | Zhang, YL; Gao ZQ(高增强) ; Gao, ZQ; Guo, Z; Zhang, HP; Zhang, ZZ; Luo, M; Hou, HF; Huang, AL; Dong, YH
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| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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| 出版日期 | 2013 |
| 卷号 | 439期号:3页码:346-350 |
| 关键词 | alpha 1-Microglobulin Crystal structure Homodimer Chromophore Interface |
| 英文摘要 | Lipocalin alpha 1-microglobulin (alpha 1M) is a conserved glycoprotein present in plasma and in the interstitial fluids of all tissues. alpha 1M is linked to a heterogeneous yellow-brown chromophore of unknown structure, and interacts with several target proteins, including alpha 1-inhibitor-3, fibronectin, prothrombin and albumin. To date, there is little knowledge about the interaction sites between alpha 1M and its partners. Here, we report the crystal structure of the human alpha 1M. Due to the crystallization occurring in a low ionic strength solution, the unidentified chromophore with heavy electron density is observed at a hydrophobic inner tube of alpha 1M. In addition, two conserved surface regions of alpha 1M are proposed as putative protein-protein interface sites. Further study is needed to unravel the detailed information about the interaction between alpha 1M and its partners. (C) 2013 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000325448800005 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/223948]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang, YL,Gao ZQ,Gao, ZQ,et al. The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2013,439(3):346-350. |
| APA | Zhang, YL.,高增强.,Gao, ZQ.,Guo, Z.,Zhang, HP.,...&董宇辉.(2013).The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,439(3),346-350. |
| MLA | Zhang, YL,et al."The crystal structure of human protein alpha 1M reveals a chromophore-binding site and two putative protein-protein interfaces".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 439.3(2013):346-350. |
入库方式： OAI收割
来源：高能物理研究所
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