Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice
文献类型:期刊论文
作者 | Zhang, X; Yang, XR; Chen Y(陈雨)![]() ![]() ![]() |
刊名 | EUROPEAN RADIOLOGY
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出版日期 | 2013 |
卷号 | 23期号:2页码:417-423 |
关键词 | Synchrotron radiation Phase-contrast imaging Diffraction-enhanced imaging Liver fibrosis X-ray |
英文摘要 | To determine whether phase-contrast X-ray imaging can be used to visualise directly the accumulated extracellular matrix proteins associated with liver fibrosis in common bile duct ligated mice. Twenty-six-week-old C57BL female mice were randomised into three groups. In groups 1 (n = 5) and 2 (n = 10), common bile duct ligation was conducted to produce secondary biliary cirrhosis. Mouse livers were then excised 15 (group 1) and 40 days (group 2) after the ligation of the common bile duct for imaging. In the control group, the livers of 5 mice were excised 40 days after the sham operation. Images were then acquired using the analyser crystal set at different positions of the rocking curve. The results show that the fibrotic septa and hepatic lobules enclosed by fibrotic septa can be visualised clearly at the whole organ level via phase-contrast X-ray imaging without any contrast agent. These results suggest that phase-contrast X-ray imaging can easily reveal the accumulated extracellular matrix proteins associated with liver fibrosis without using any contrast agent and has great potential in the study of liver fibrosis. aEuro cent Phase-contrast X-ray imaging may aid the study of liver fibrosis. aEuro cent It provides higher contrast and spatial resolution (ca. 10 mu m) than conventional radiography. aEuro cent It can reveal fibrotic septa, small ducts and vessels without using contrast agents. aEuro cent Results in animals now need to be translated to human clinical practice. |
学科主题 | Radiology, Nuclear Medicine & Medical Imaging |
收录类别 | SCI |
WOS记录号 | WOS:000312882200016 |
公开日期 | 2016-05-03 |
源URL | [http://ir.ihep.ac.cn/handle/311005/223977] ![]() |
专题 | 高能物理研究所_多学科研究中心 |
推荐引用方式 GB/T 7714 | Zhang, X,Yang, XR,Chen Y,et al. Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice[J]. EUROPEAN RADIOLOGY,2013,23(2):417-423. |
APA | Zhang, X.,Yang, XR.,陈雨.,袁清习.,朱佩平.,...&Peng, WJ.(2013).Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice.EUROPEAN RADIOLOGY,23(2),417-423. |
MLA | Zhang, X,et al."Visualising liver fibrosis by phase-contrast X-ray imaging in common bile duct ligated mice".EUROPEAN RADIOLOGY 23.2(2013):417-423. |
入库方式: OAI收割
来源:高能物理研究所
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