Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice
文献类型：期刊论文
| 作者 | Xue, YY; Zhang, SS; Huang, YM; Zhang, T; Liu, XR; Hu, YY; Zhang, ZY; Tang, M;张智勇 |
| 刊名 | JOURNAL OF APPLIED TOXICOLOGY
 |
| 出版日期 | 2012 |
| 卷号 | 32期号:11页码:890-899 |
| 关键词 | silver nanoparticles acute toxic effects gender-related biokinetics tissue distribution mice |
| 英文摘要 | This study evaluated the acute toxicity and biokinetics of intravenously administered silver nanoparticles (AgNPs) in mice. Mice were exposed to different dosages of AgNPs (7.5, 30 or 120?mg kg-1). Toxic effects were assessed via general behavior, serum biochemical parameters and histopathological observation of the mice. Biokinetics and tissue distribution of AgNPs were evaluated at a dose of 120?mg kg-1 in both male and female mice. Inductively coupled plasmamass spectrometry (ICP-MS) was used to determine silver concentrations in blood and tissue samples collected at predetermined time intervals. After 2?weeks, AgNPs exerted no obvious acute toxicity in the mice. However, inflammatory reactions in lung and liver cells were induced in mice treated at the 120?mg kg-1 dose level. The highest silver levels were observed in the spleen, followed by liver, lungs and kidneys. The elimination half-lives and clearance of AgNPs were 15.6?h and 1.0?ml h-1 g-1 for male mice and 29.9?h and 0.8?ml h-1 g-1 for female mice. These results indicated that AgNPs could be distributed extensively to various tissues in the body, but primarily in the spleen and liver. Furthermore, there appears to be gender-related differences in the biokinetic profiles in blood and distribution in lungs and kidneys following an intravenous injection of AgNPs. The data from this study provides information on toxicity and biodistribution of AgNPs following intravenous administration in mice, which represents the worst case scenario of toxicity among all the different administration routes, and may shed light in the future use of products containing AgNPs in humans. Copyright (c) 2012 John Wiley & Sons, Ltd. |
| 学科主题 | Toxicology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000309190200003 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224076]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Xue, YY,Zhang, SS,Huang, YM,et al. Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice[J]. JOURNAL OF APPLIED TOXICOLOGY,2012,32(11):890-899. |
| APA | Xue, YY.,Zhang, SS.,Huang, YM.,Zhang, T.,Liu, XR.,...&Tang, M；张智勇.(2012).Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice.JOURNAL OF APPLIED TOXICOLOGY,32(11),890-899. |
| MLA | Xue, YY,et al."Acute toxic effects and gender-related biokinetics of silver nanoparticles following an intravenous injection in mice".JOURNAL OF APPLIED TOXICOLOGY 32.11(2012):890-899. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。