Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex
文献类型：期刊论文
| 作者 | Li, MJ; Lan, TY; Lin, ZS; Yi, CQ; Chen, GN |
| 刊名 | JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
 |
| 出版日期 | 2013 |
| 卷号 | 18期号:8页码:993-1003 |
| 关键词 | Copper(II) complex DNA binding Cytotoxicity Nucleolytic cleavage |
| 英文摘要 | A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV-vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects. |
| 学科主题 | Biochemistry & Molecular Biology; Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000327406000012 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224090]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Li, MJ,Lan, TY,Lin, ZS,et al. Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex[J]. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,2013,18(8):993-1003. |
| APA | Li, MJ,Lan, TY,Lin, ZS,Yi, CQ,&Chen, GN.(2013).Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex.JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY,18(8),993-1003. |
| MLA | Li, MJ,et al."Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex".JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 18.8(2013):993-1003. |
入库方式： OAI收割
来源：高能物理研究所
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