The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6
文献类型：期刊论文
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| 作者 | Zhang H(张衡) ; Gao ZQ(高增强); Wang WJ(王文佳); Zhang, H; Gao, ZQ; Wang, WJ; Liu, GF; Shtykova, EV; Xu, JH; Li, LF
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| 刊名 | FEBS LETTERS
 ; FEBS LETTERS
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| 出版日期 | 2012 ; 2012 |
| 卷号 | 586期号:8页码:1147-1153 |
| 关键词 | MPN domain JAMM motif COP9 signalosome CSN6 Crystal structure MPN domain JAMM motif COP9 signalosome CSN6 Crystal structure |
| DOI | 10.1016/j.febslet.2012.03.029 |
| 英文摘要 | The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5 angstrom crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease. Structured summary of protein interactions: CSN6 and CSN6 bind by x-ray crystallography (View interaction) CSN6 and CSN6 bind by x ray scattering (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.; The COP9 signalosome (CSN) is a multiprotein complex containing eight subunits and is highly conserved from fungi to human. CSN is proposed to widely participate in many physiological processes, including protein degradation, DNA damage response and signal transduction. Among those subunits, only CSN5 and CSN6 belong to JAMM family. CSN5 possesses isopeptidase activity, but CSN6 lacks this ability. Here we report the 2.5 angstrom crystal structure of MPN domain from Drosophila melanogaster CSN6. Structural comparison with other MPN domains, along with bioinformation analysis, suggests that MPN domain from CSN6 may serve as a scaffold instead of a metalloprotease. Structured summary of protein interactions: CSN6 and CSN6 bind by x-ray crystallography (View interaction) CSN6 and CSN6 bind by x ray scattering (View interaction) (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology ; Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 收录类别 | SCI |
| WOS记录号 | WOS:000303106100010 ; WOS:000303106100010 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224110]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang H,Gao ZQ,Wang WJ,et al. The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6, The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6[J]. FEBS LETTERS, FEBS LETTERS,2012, 2012,586, 586(8):1147-1153, 1147-1153. |
| APA | 张衡.,高增强.,王文佳.,Zhang, H.,Gao, ZQ.,...&董宇辉.(2012).The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6.FEBS LETTERS,586(8),1147-1153. |
| MLA | 张衡,et al."The crystal structure of the MPN domain from the COP9 signalosome subunit CSN6".FEBS LETTERS 586.8(2012):1147-1153. |
入库方式： OAI收割
来源：高能物理研究所
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