Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway
文献类型：期刊论文
| 作者 | Yang, KN; Cao, WP; Hao, XH; Xue, X; Zhao, J; Liu, J; Zhao, YL; Meng, J; Sun, BY; Zhang, JC |
| 刊名 | NANOSCALE
 |
| 出版日期 | 2013 |
| 卷号 | 5期号:3页码:1205-1212 |
| 英文摘要 | Although endohedral metallofullerenol [Gd@C-82(OH)(22)](n) nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these nanoparticles act in bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that [Gd@C-82(OH)(22)](n) nanoparticles facilitated the differentiation of MSCs toward osteoblasts, as evidenced by the enhancement of alkaline phosphatase (ALP) activity and mineralized nodule formation upon [Gd@C-82(OH)(22)](n) nanoparticle treatment. Mechanistically, the effect of [Gd@C-82(OH)(22)](n) nanoparticles on ALP activity was inhibited by the addition of noggin as an inhibitor of the BMP signaling pathway. Moreover, the in vivo results of the ovariectomized rats further indicated that [Gd@C-82(OH)(22)](n) nanoparticles effectively improved bone density and prevented osteoporosis. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000313803000051 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224116]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yang, KN,Cao, WP,Hao, XH,et al. Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway[J]. NANOSCALE,2013,5(3):1205-1212. |
| APA | Yang, KN.,Cao, WP.,Hao, XH.,Xue, X.,Zhao, J.,...&孙宝云.(2013).Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway.NANOSCALE,5(3),1205-1212. |
| MLA | Yang, KN,et al."Metallofullerene nanoparticles promote osteogenic differentiation of bone marrow stromal cells through BMP signaling pathway".NANOSCALE 5.3(2013):1205-1212. |
入库方式： OAI收割
来源：高能物理研究所
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