Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents
文献类型：期刊论文
| 作者 | He R(何睿); Xing GM(邢更妹) ; He, R; Xing, GM; Wang, XX; Jiao, YH; Zhao, H; Yuan, H; Wang, SK; Dong, JQ
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2013 |
| 卷号 | 13期号:2页码:1549-1554 |
| 关键词 | Metallofullerene Bingel-Hirsch Reaction Paramagnetic Contrast Agent Relaxivity |
| 英文摘要 | Water-soluble malonate multiadducts of paramagnetic gadolinium endohedral metallofullerene, Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8), were synthesized by Bingel-Hirsch reaction. Gd@C-82 was firstly reacted with diethyl bromomalonate in the presence of alkali metal hydride to produce malonic ester multiadducted derivatives, Gd@C-82[C(OOCH2CH3)(2)](x) (x = 3-8), by Bingel reaction. They were isolated and purified to obtain Gd@C-82[C(COOCH2CH3)(2)](6) and Gd@C-82[C(COOCH2CH3)(2)](8) by silica-gel column chromatography with a gradient elution method, which were subsequently hydrolyzed to yield water-soluble Gd@C-82[C(COOH)(2)](6) and Gd@C-82[C(COOH)(2)](8) by Hirsch reaction. The structures of the derivatives were characterized by Fourier transform infrared spectrometry and matrix assisted laser desorption ionization time-of-flight mass spectrometry. The longitudinal relaxivities of Gd@C-82[C(COOH)(2)](8) and Gd@C-82[C(COOH)(2)](6), in buffer solution, were found to be 18.20 and 11.08 mM(-1) s(-1) concentration range between 0.001-0.025 mM Gd, and to be 12.71 and 6.73 mM(-1) s(-1) between 0.050-0.200 mM Gd, respectively. The results showed that the measured relaxivities for malonate derivatives of Gd@C-82 were dependent on the concentration of these solutions and the number of hydrophilic carboxyl groups appended on the surface of the Gd@C-82 cage. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000318254500176 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224150]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | He R,Xing GM,He, R,et al. Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(2):1549-1554. |
| APA | 何睿.,邢更妹.,He, R.,Xing, GM.,Wang, XX.,...&董金泉.(2013).Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(2),1549-1554. |
| MLA | 何睿,et al."Synthesis and Evaluation of Bingel-Hirsch Multiadducts of Paramagnetic Gadofullerene as Potential Magnetic Resonance Imaging Contrast Agents".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.2(2013):1549-1554. |
入库方式： OAI收割
来源：高能物理研究所
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