Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles
文献类型：期刊论文
| 作者 | Xu, Q; Liu, YX; Su, SS; Li, W; Chen, CY; Wu, Y; 李炜(多 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2012 |
| 卷号 | 33期号:5页码:1627-1639 |
| 关键词 | Hyperbranched copolymer nanoparticle Tumor-targeting cRGDfK Transferrin Intrinsic fluorescence Controlled drug release |
| 英文摘要 | Targeted delivery strategies are becoming increasingly important. Herein, a novel hyperbranched amphiphilic poly[(amine-ester)-co-(D,L-lactide)]/1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine copolymer (HPAE-co-PLA/DPPE) with RGD peptide (cRGDfK) and transferrin (If) on the periphery was synthesized and used to prepare paclitaxel-loaded nanoparticles (NPs) for dual-targeting chemotherapy. These NPs show satisfactory size distribution, high encapsulated efficiency and a pH-dependent release profile. The intrinsic fluorescence of the hyperbranched copolymer renders the detection and tracking of NPs in vitro and in vivo conveniently. In vitro cytotoxicity studies proved that the presence of cRGDfK enhanced the cytotoxic efficiency by 10 folds in delta(v)beta(3) integrin over-expressed human umbilical vein endothelial cells, while If improved cytotoxicity by 2 folds in If receptor over-expressed human cervical carcinoma cells. The drug-loaded NPs can be efficiently transported into the vascular endothelial cells and the target tumor cells. These results indicate that the cRGDfK and If decorated HPAE-co-PLA/DPPE could deliver chemotherapies specifically inside the cell via receptor-mediated endocytosis with greater efficacy. Therefore, such a fluorescent nanocarrier prepared from non-cytotoxic and biodegradable polymers is promising for drug delivery in tumor therapy. (C) 2011 Elsevier Ltd. All rights reserved. |
| 学科主题 | Engineering; Materials Science |
| 收录类别 | SCI |
| WOS记录号 | WOS:000300474000042 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224158]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Xu, Q,Liu, YX,Su, SS,et al. Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles[J]. BIOMATERIALS,2012,33(5):1627-1639. |
| APA | Xu, Q.,Liu, YX.,Su, SS.,Li, W.,Chen, CY.,...&李炜.(2012).Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.BIOMATERIALS,33(5),1627-1639. |
| MLA | Xu, Q,et al."Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles".BIOMATERIALS 33.5(2012):1627-1639. |
入库方式： OAI收割
来源：高能物理研究所
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