Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species
文献类型：期刊论文
| 作者 | Yan L(晏亮) ; Gu ZJ(谷战军); 赵宇亮;Yan, L; Gu, ZJ; Zhao, YL
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| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2013 |
| 卷号 | 8期号:SI10页码:2342-2353 |
| 关键词 | nanoparticles oxygen reactive intermediates reaction mechanisms toxicity |
| 英文摘要 | As more and more nanomaterials with novel physicochemical properties or new functions are created and used in different research fields and industrial sectors, the scientific and public concerns about their toxic effects on human health and the environment are also growing quickly. In the past decade, the study of the toxicological properties of nanomaterials/nanoparticles has formed a new research field: nanotoxicology. However, most of the data published relate to toxicological phenomena and there is less understanding of the underlying mechanism for nanomaterial-induced toxicity. Nanomaterial-induced reactive oxygen species (ROS) play a key role in cellular and tissue toxicity. Herein, we classify the pathways for intracellular ROS production by nanomaterials into 1)the direct generation of ROS through nanomaterial-catalyzed free-radical reactions in cells, and 2)the indirect generation of ROS through disturbing the inherent biochemical equilibria in cells. We also discuss the chemical mechanisms associated with above pathways of intracellular ROS generation, from the viewpoint of the high reactivity of atoms on the nanosurface. We hope to aid in the understanding of the chemical origin of nanotoxicity to provide new insights for chemical and material scientists for the rational design and creation of safer and greener nanomaterials. |
| 学科主题 | Chemistry |
| 收录类别 | SCI |
| WOS记录号 | WOS:000324748600009 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224200]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Yan L,Gu ZJ,赵宇亮；Yan, L,et al. Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species[J]. CHEMISTRY-AN ASIAN JOURNAL,2013,8(SI10):2342-2353. |
| APA | 晏亮,谷战军,赵宇亮；Yan, L,Gu, ZJ,&Zhao, YL.(2013).Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species.CHEMISTRY-AN ASIAN JOURNAL,8(SI10),2342-2353. |
| MLA | 晏亮,et al."Chemical Mechanisms of the Toxicological Properties of Nanomaterials: Generation of Intracellular Reactive Oxygen Species".CHEMISTRY-AN ASIAN JOURNAL 8.SI10(2013):2342-2353. |
入库方式： OAI收割
来源：高能物理研究所
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