Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications
文献类型：期刊论文
| 作者 | Gu ZJ(谷战军) ; Yan L(晏亮); Tian G(田甘); 赵宇亮;Gu, ZJ; Yan, L; Tian, G; Li, SJ; Chai, ZF; Zhao, YL
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| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2013 |
| 卷号 | 25期号:SI28页码:3758-3779 |
| 关键词 | upconversion nanoparticles multifunction bioimaging drug delivery nanoprobes |
| 英文摘要 | Lanthanide (Ln) doped upconversion nanoparticles (UCNPs) have attracted enormous attention in the recent years due to their unique upconversion luminescent properties that enable the conversion of low-energy photons (near infrared photons) into high-energy photons (visible to ultraviolet photons) via the multiphoton processes. This feature makes them ideal for bioimaging applications with attractive advantages such as no autofluorescence from biotissues and a large penetration depth. In addition, by incorporating advanced features, such as specific targeting, multimodality imaging and therapeutic delivery, the application of UCNPs has been dramatically expanded. In this review, we first summarize the recent developments in the fabrication strategies of UCNPs with the desired size, enhanced and tunable upconversion luminescence, as well as the combined multifunctionality. We then discuss the chemical methods applied for UCNPs surface functionalization to make these UCNPs biocompatible and water-soluble, and further highlight some representative examples of using UCNPs for in vivo bioimaging, NIR-triggered drug/gene delivery applications and photodynamic therapy. In the perspectives, we discuss the need of systematically nanotoxicology data for rational designs of UCNPs materials, their surface chemistry in safer biomedical applications. The UCNPs can actually provide an ideal multifunctionalized platform for solutions to many key issues in the front of medical sciences such as theranostics, individualized therapeutics, multimodality medicine, etc. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000327749400002 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224244]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Gu ZJ,Yan L,Tian G,et al. Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications[J]. ADVANCED MATERIALS,2013,25(SI28):3758-3779. |
| APA | 谷战军.,晏亮.,田甘.,赵宇亮；Gu, ZJ.,Yan, L.,...&Zhao, YL.(2013).Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications.ADVANCED MATERIALS,25(SI28),3758-3779. |
| MLA | 谷战军,et al."Recent Advances in Design and Fabrication of Upconversion Nanoparticles and Their Safe Theranostic Applications".ADVANCED MATERIALS 25.SI28(2013):3758-3779. |
入库方式： OAI收割
来源：高能物理研究所
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