The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity
文献类型：期刊论文
| 作者 | Wang YJ(王雅洁); Wang Z(王喆); Wang, Y; Wang, Z; Joshi, BH; Puri, RK; Stultz, B; Yuan, Q; Bai, Y; Zhou, P |
| 刊名 | ONCOGENE
 |
| 出版日期 | 2013 |
| 卷号 | 32期号:33页码:3857-3866 |
| 关键词 | Apoptosis Caliban p53 tumor suppressor |
| 英文摘要 | We previously identified Caliban (Clbn) as the Drosophila homolog of human Serologically defined colon cancer antigen 1 gene and demonstrated that it could function as a tumor suppressor in human non-small-cell lung cancer (NSCLC) cells, although its mode of action was unknown. Herein, we identify roles for Clbn in DNA damage response. We generate clbn knockout flies using homologous recombination and demonstrate that they have a heightened sensitivity to irradiation. We show that normal Clbn function facilitates both p53-dependent and -independent DNA damage-induced apoptosis. Clbn coordinates different apoptosis pathways, showing a two-stage upregulation following DNA damage. Clbn has proapoptotic functions, working with both caspase and the proapoptotic gene Hid. Finally, ecotopic expression of clbn(+) in NSCLC cells suppresses tumor formation in athymic nude mice. We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways. |
| 学科主题 | Biochemistry & Molecular Biology; Oncology; Cell Biology; Genetics & Heredity |
| 收录类别 | SCI |
| WOS记录号 | WOS:000323210200008 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224246]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Wang YJ,Wang Z,Wang, Y,et al. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity[J]. ONCOGENE,2013,32(33):3857-3866. |
| APA | 王雅洁.,王喆.,Wang, Y.,Wang, Z.,Joshi, BH.,...&秘晓林.(2013).The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity.ONCOGENE,32(33),3857-3866. |
| MLA | 王雅洁,et al."The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity".ONCOGENE 32.33(2013):3857-3866. |
入库方式： OAI收割
来源：高能物理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。