A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells
文献类型：期刊论文
| 作者 | Zhang, XY; He X(何潇) ; Li YY(李媛媛); Zhang ZY(张智勇); 马宇辉;He, X; Li, YY; Zhang, ZY; Ma, YH; Li, FM; Liu, JM
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| 刊名 | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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| 出版日期 | 2013 |
| 卷号 | 13期号:8页码:5254-5259 |
| 关键词 | Carbon Dots Cytotoxicity Membrane Injury Oxidative Damage |
| 英文摘要 | The labeling of living cells with carbon nanoparticles has been increasingly studied both in vivo and in vitro, but concerns about the potential cytotoxicity of these nanoprobes are also increasing. In this study, the fluorescent carbon dots (CDs) without surface modification was synthesized and evaluated for its cytotoxicity. Indicators including cell viability, total reactive oxygen species (ROS), glutathione, malondialdehyde and lactate dehydrogenase were assessed using human bronchial epithelial (16HBE) cell line. Our results showed that CDs preferred to locate on the surface of cells, which significantly increased the membrane permeability of 16HBE cells. CDs exposure could further induce oxidative stress, exhaust the antioxidant defenses of cells and finally lead to decreased cell viability. Therefore, surface modification of CDs is needed to minimize its cytotoxicity. The present work is useful for the development of new strategies towards the in vitro and in vivo applications of CDs for optical imaging and drug delivery. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 收录类别 | SCI |
| WOS记录号 | WOS:000320632200005 |
| 公开日期 | 2016-05-03 |
| 源URL | [http://ir.ihep.ac.cn/handle/311005/224256]  |
| 专题 | 高能物理研究所_多学科研究中心 |
| 推荐引用方式 GB/T 7714 | Zhang, XY,He X,Li YY,et al. A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2013,13(8):5254-5259. |
| APA | Zhang, XY.,何潇.,李媛媛.,张智勇.,马宇辉；He, X.,...&Liu, JM.(2013).A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,13(8),5254-5259. |
| MLA | Zhang, XY,et al."A Cytotoxicity Study of Fluorescent Carbon Nanodots Using Human Bronchial Epithelial Cells".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 13.8(2013):5254-5259. |
入库方式： OAI收割
来源：高能物理研究所
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